AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 284: H2412-H2418, 2003. First published February 21, 2003; doi:10.1152/ajpheart.00660.2002
0363-6135/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/6/H2412    most recent
00660.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (5)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Miyamoto, T.
Right arrow Articles by Sunagawa, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Miyamoto, T.
Right arrow Articles by Sunagawa, K.
Vol. 284, Issue 6, H2412-H2418, June 2003

High plasma norepinephrine attenuates the dynamic heart rate response to vagal stimulation

Tadayoshi Miyamoto1,2, Toru Kawada1, Hiroshi Takaki1, Masashi Inagaki1, Yusuke Yanagiya1,3, Yintie Jin1,3, Masaru Sugimachi1, and Kenji Sunagawa1

1 Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Osaka 565-8565; 2 Japan Space Forum, Tokyo 105-0013; and 3 Organization for Pharmaceutical Safety and Research, Tokyo 100-0013, Japan

To better understand the pathophysiological significance of high plasma norepinephrine (NE) concentration in regulating heart rate (HR), we examined the interactions between high plasma NE and dynamic vagal control of HR. In anesthetized rabbits with sinoaortic denervation and vagotomy, using a binary white noise sequence (0-10 Hz) for 10 min, we stimulated the right vagus and estimated the transfer function from vagal stimulation to HR response. The transfer function approximated a first-order low-pass filter with pure delay. Infusion of NE (100 µg · kg-1 · h-1 iv) attenuated the dynamic gain from 6.2 ± 0.8 to 3.9 ± 1.2 beats · min-1 · Hz-1 (n = 7, P < 0.05) without affecting the corner frequency or pure delay. Simultaneous intravenous administration of phentolamine (1 mg · kg-1 · h-1) and NE (100 µg · kg-1 · h-1) abolished the inhibitory effect of NE on the dynamic gain (6.3 ± 0.8 vs. 6.4 ± 1.3 beats · min-1 · Hz-1, not significant, n = 7). The inhibitory effect of NE at infusion rates of 10, 50, and 100 µg · kg-1 · h-1 on dynamic vagal control of HR was dose-dependent (n = 5). In conclusion, high plasma NE attenuated the dynamic HR response to vagal stimulation, probably via activation of alpha -adrenergic receptors on the preganglionic and/or postganglionic cardiac vagal nerve terminals.

systems analysis; transfer function; alpha -adrenergic receptors; heart rate variability; rabbit


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Mizuno, A. Kamiya, T. Kawada, T. Miyamoto, S. Shimizu, and M. Sugimachi
Muscarinic potassium channels augment dynamic and static heart rate responses to vagal stimulation
Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1564 - H1570.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Buchheit, P. B. Laursen, and S. Ahmaidi
Parasympathetic reactivation after repeated sprint exercise
Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H133 - H141.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. A. Sala-Mercado, M. Ichinose, R. L. Hammond, T. Ichinose, M. Pallante, L. W. Stephenson, D. S. O'Leary, and F. Iellamo
Muscle metaboreflex attenuates spontaneous heart rate baroreflex sensitivity during dynamic exercise
Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2867 - H2873.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. Ogoh, J. P Fisher, E. A Dawson, M. J White, N. H Secher, and P. B Raven
Autonomic nervous system influence on arterial baroreflex control of heart rate during exercise in humans
J. Physiol., July 15, 2005; 566(2): 599 - 611.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. Miyamoto, T. Kawada, Y. Yanagiya, M. Inagaki, H. Takaki, M. Sugimachi, and K. Sunagawa
Cardiac sympathetic nerve stimulation does not attenuate dynamic vagal control of heart rate via {alpha}-adrenergic mechanism
Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H860 - H865.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.