AJP - Heart Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 285: H614-H620, 2003. First published April 10, 2003; doi:10.1152/ajpheart.00823.2002
0363-6135/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
285/2/H614    most recent
00823.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (8)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chemla, D.
Right arrow Articles by Nitenberg, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chemla, D.
Right arrow Articles by Nitenberg, A.

Contribution of systemic vascular resistance and total arterial compliance to effective arterial elastance in humans

Denis Chemla,1,2 Isabelle Antony,3 Yves Lecarpentier,1 and Alain Nitenberg3

1Service de Physiologie Cardio-Respiratoire, Centre Hospitalier Universitaire de Bicêtre, Assistance Publique-Hôpitaux de Paris, 94 275 Le Kremlin-Bicêtre; 2Unité Propre de l'Enseignement Supérieur 2705, Université Paris Sud 11, 92 141 Clamart; and 3Service de Physiologie et d'Explorations Fonctionnelles, Centre Hospitalier Universitaire Jean Verdier, Assistance Publique-Hôpitaux de Paris, Université Paris 13, 93 143 Bondy, France

Submitted 13 September 2002 ; accepted in final form 3 April 2003

The respective contribution of systemic vascular resistance (R) and total arterial compliance (C) to the arterial load remains to be established in humans. Effective arterial elastance (Ea), i.e., the left ventricular end-systolic pressure (LVESP)-over-stroke volume ratio, is a reliable estimate of arterial load. It is widely accepted that Ea mainly relates to mean aortic pressure (MAP) and thus to the R-to-T ratio (R/T ratio), where T is cycle length. We tested the contribution of R/T and 1/C to Ea in 20 normotensive and 46 hypertensive subjects (MAP range: 84–160 mmHg). The multilinear model applied (Ea = 1.00R/T + 0.42/C – 0.04; r2 = 0.97). The sensitivity of Ea to a change in R/T was 2.5 times higher than to a similar change in 1/C in both normotensive and hypertensive adults. The LVESP was more strongly related to systolic aortic pressure (SAP; r2 = 0.94) than to MAP (r2 = 0.83), and LVESP matched 90% SAP (bias = 0 ± 5mmHg). An alternative model of Ea is proposed, in which Ea is proportional to the heart rate x SAP product-over-cardiac index ratio whatever the MAP.

rate-pressure product; cardiac index; ventriculoarterial coupling; pulse pressure; cardiac cycle length


Address for reprint requests and other correspondence: D. Chemla, Service d'Explorations Fonctionnelles Cardio-Respiratoires, Université de Paris XI, Hôpital de Bicêtre, 94 275 Le Kremlin-Bicêtre Cedex, France (E-mail: denis.chemla{at}bct.ap-hop-paris.fr).




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
P. D. Chantler, E. G. Lakatta, and S. S. Najjar
Arterial-ventricular coupling: mechanistic insights into cardiovascular performance at rest and during exercise
J Appl Physiol, October 1, 2008; 105(4): 1342 - 1351.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. Otsuki, S. Maeda, M. Iemitsu, Y. Saito, Y. Tanimura, R. Ajisaka, and T. Miyauchi
Systemic arterial compliance, systemic vascular resistance, and effective arterial elastance during exercise in endurance-trained men
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2008; 295(1): R228 - R235.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. Chemla, I. Antony, K. Zamani, and A. Nitenberg
Mean aortic pressure is the geometric mean of systolic and diastolic aortic pressure in resting humans
J Appl Physiol, December 1, 2005; 99(6): 2278 - 2284.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
V. Muthurangu, D. Atkinson, M. Sermesant, M. E. Miquel, S. Hegde, R. Johnson, R. Andriantsimiavona, A. M. Taylor, E. Baker, R. Tulloh, et al.
Measurement of total pulmonary arterial compliance using invasive pressure monitoring and MR flow quantification during MR-guided cardiac catheterization
Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1301 - H1306.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. Briand, J. G. Dumesnil, L. Kadem, A. G. Tongue, R. Rieu, D. Garcia, and P. Pibarot
Reduced Systemic Arterial Compliance Impacts Significantly on Left Ventricular Afterload and Function in Aortic Stenosis: Implications for Diagnosis and Treatment
J. Am. Coll. Cardiol., July 19, 2005; 46(2): 291 - 298.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
K. L. Peterson
Severe Calcific Aortic Stenosis: Left Ventricular Afterload and its Quantification
J. Am. Coll. Cardiol., July 19, 2005; 46(2): 299 - 301.
[Full Text] [PDF]

Home page
 HeartHome page
L Kadem, J G Dumesnil, R Rieu, L-G Durand, D Garcia, and P Pibarot
Impact of systemic hypertension on the assessment of aortic stenosis
Heart, March 1, 2005; 91(3): 354 - 361.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.