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Am J Physiol Heart Circ Physiol 285: H614-H620, 2003. First published April 10, 2003; doi:10.1152/ajpheart.00823.2002
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Contribution of systemic vascular resistance and total arterial compliance to effective arterial elastance in humans

Denis Chemla,1,2 Isabelle Antony,3 Yves Lecarpentier,1 and Alain Nitenberg3

1Service de Physiologie Cardio-Respiratoire, Centre Hospitalier Universitaire de Bicêtre, Assistance Publique-Hôpitaux de Paris, 94 275 Le Kremlin-Bicêtre; 2Unité Propre de l'Enseignement Supérieur 2705, Université Paris Sud 11, 92 141 Clamart; and 3Service de Physiologie et d'Explorations Fonctionnelles, Centre Hospitalier Universitaire Jean Verdier, Assistance Publique-Hôpitaux de Paris, Université Paris 13, 93 143 Bondy, France

Submitted 13 September 2002 ; accepted in final form 3 April 2003

The respective contribution of systemic vascular resistance (R) and total arterial compliance (C) to the arterial load remains to be established in humans. Effective arterial elastance (Ea), i.e., the left ventricular end-systolic pressure (LVESP)-over-stroke volume ratio, is a reliable estimate of arterial load. It is widely accepted that Ea mainly relates to mean aortic pressure (MAP) and thus to the R-to-T ratio (R/T ratio), where T is cycle length. We tested the contribution of R/T and 1/C to Ea in 20 normotensive and 46 hypertensive subjects (MAP range: 84–160 mmHg). The multilinear model applied (Ea = 1.00R/T + 0.42/C – 0.04; r2 = 0.97). The sensitivity of Ea to a change in R/T was 2.5 times higher than to a similar change in 1/C in both normotensive and hypertensive adults. The LVESP was more strongly related to systolic aortic pressure (SAP; r2 = 0.94) than to MAP (r2 = 0.83), and LVESP matched 90% SAP (bias = 0 ± 5mmHg). An alternative model of Ea is proposed, in which Ea is proportional to the heart rate x SAP product-over-cardiac index ratio whatever the MAP.

rate-pressure product; cardiac index; ventriculoarterial coupling; pulse pressure; cardiac cycle length


Address for reprint requests and other correspondence: D. Chemla, Service d'Explorations Fonctionnelles Cardio-Respiratoires, Université de Paris XI, Hôpital de Bicêtre, 94 275 Le Kremlin-Bicêtre Cedex, France (E-mail: denis.chemla{at}bct.ap-hop-paris.fr).




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