HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 285/2/H621    most recent 01063.2002v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (19) Citing Articles via Google Scholar Google Scholar Articles by Fonseca, C. G. Articles by Young, A. A. Search for Related Content PubMed PubMed Citation Articles by Fonseca, C. G. Articles by Young, A. A.

Aging alters patterns of regional nonuniformity in LV strain relaxation: a 3-D MR tissue tagging study

¹Department of Anatomy with Radiology and ²Department of Medicine, Faculty of Medical and Health Sciences, The University of Auckland, and ³Department of Cardiac Radiology, Green Lane Hospital, Auckland, New Zealand

Submitted 9 December 2002 ; accepted in final form 8 April 2003

Although age-related impairment of diastolic function is well documented, patterns of regional tissue relaxation impairment with age have not been characterized. MRI tissue tagging with a regional three-dimensional (3-D) analysis was performed in 15 younger (age 19–26 yr) and 16 older (age 60–74 yr) normal, healthy volunteers. The peak rate of relaxation of circumferential strain (R_C) was decreased in the older group (on average, 105 ± 28 vs. 163 ± 18 %/s for older vs. younger, mean ± SD, P < 0.001) to a greater extent in the lateral wall than in the septum (P = 0.016) and to a greater extent in the apex than in the base (P < 0.001). Peak rate of relaxation of longitudinal strain (R_L) was also reduced with age (94 ± 27 vs. 155 ± 18 %/s, P < 0.001) to a greater extent in the apex than in the base (P < 0.001). Both R_C and R_L were greater in the apex than in the base only in the younger subjects (P < 0.001 for each). Peak rate of torsion reversal (R_T) was reduced with age (74 ± 16 vs. 91 ± 15 degrees/s, P = 0.006) to a greater extent in the base than in the apex (P = 0.035). An increase in regional asynchrony in time to R_C and time to R_L (P < 0.001 for each), but not time to R_T, occurred with age. Thus patterns of regional nonuniformity of myocardial relaxation are altered in a consistent fashion with aging.

myocardium; magnetic resonance imaging; diastole; elderly; left ventricular

This article has been cited by other articles:

				T. A. Dorfman, B. D. Rosen, M. A. Perhonen, T. Tillery, R. McColl, R. M. Peshock, and B. D. Levine Diastolic suction is impaired by bed rest: MRI tagging studies of diastolic untwisting J Appl Physiol, April 1, 2008; 104(4): 1037 - 1044. [Abstract] [Full Text] [PDF]

				M. Tumkosit, C. G. Martin, E. Bayram, T. M. Morgan, K. S. Lane, P. Rerkpattanapipat, C. A. Hamilton, K. M. Link, and W. G. Hundley Left Ventricular Spherical Remodeling and Apical Myocardial Relaxation: Cardiovascular MR Imaging Measurement of Myocardial Segments Radiology, August 1, 2007; 244(2): 411 - 418. [Abstract] [Full Text] [PDF]

				M. J.W. Gotte, T. Germans, I. K. Russel, J. J.M. Zwanenburg, J. T. Marcus, A. C. van Rossum, and D. J. van Veldhuisen Myocardial Strain and Torsion Quantified by Cardiovascular Magnetic Resonance Tissue Tagging: Studies in Normal and Impaired Left Ventricular Function J. Am. Coll. Cardiol., November 21, 2006; 48(10): 2002 - 2011. [Abstract] [Full Text] [PDF]

				J. Lumens, T. Delhaas, T. Arts, B. R. Cowan, and A. A. Young Impaired subendocardial contractile myofiber function in asymptomatic aged humans, as detected using MRI Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1573 - H1579. [Abstract] [Full Text] [PDF]

				V. R.S. Fernandes, J. F. Polak, T. Edvardsen, B. Carvalho, A. Gomes, D. A. Bluemke, K. Nasir, D. H. O'Leary, and J. A.C. Lima Subclinical Atherosclerosis and Incipient Regional Myocardial Dysfunction in Asymptomatic Individuals: The Multi-Ethnic Study of Atherosclerosis (MESA) J. Am. Coll. Cardiol., June 20, 2006; 47(12): 2420 - 2428. [Abstract] [Full Text] [PDF]

				K. Serri, P. Reant, M. Lafitte, M. Berhouet, V. Le Bouffos, R. Roudaut, and S. Lafitte Global and Regional Myocardial Function Quantification by Two-Dimensional Strain: Application in Hypertrophic Cardiomyopathy J. Am. Coll. Cardiol., March 21, 2006; 47(6): 1175 - 1181. [Abstract] [Full Text] [PDF]

				B. D. Rosen, B. L. Gerber, T. Edvardsen, E. Castillo, L. C. Amado, K. Nasir, D. L. Kraitchman, N. F. Osman, D. A. Bluemke, and J. A. C. Lima Late systolic onset of regional LV relaxation demonstrated in three-dimensional space by MRI tissue tagging Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1740 - H1746. [Abstract] [Full Text] [PDF]

				J. J. M. Zwanenburg, M. J. W. Gotte, J. P. A. Kuijer, R. M. Heethaar, A. C. van Rossum, and J. T. Marcus Timing of cardiac contraction in humans mapped by high-temporal-resolution MRI tagging: early onset and late peak of shortening in lateral wall Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1872 - H1880. [Abstract] [Full Text] [PDF]