| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1Department of Biomedical Engineering, University of California, 92697-2715; and 2Department of Radiological Science, University of California, Irvine, California 92697-5000
Submitted 30 January 2003 ; accepted in final form 25 April 2003
The objective of this study was to determine the effect of passive
myocardium on the coronary arteries under distension and compression. To
simulate distension and compression, we placed a diastolic-arrested heart in a
Lucite box, where both the intravascular pressure and external (box) pressure
were varied independently and expressed as a pressure difference (
P =
intravascular pressure – box pressure). The P-cross-sectional
area relationship of the first several generations of porcine coronary
arteries and the P-volume relationship of the coronary arterial tree
(vessels >0.5 mm in diameter) were determined using a video densitometric
technique in the range of +150 to –150 mmHg. The vasodilated left
anterior descending (LAD) coronary artery of six KCl-arrested hearts were
perfused with iodine and 3% Cab-O-Sil. The intravascular pressure was varied
in a triangular pattern, whereas the absolute cross-sectional area of each
vessel and the total arterial volume were calculated using video densitometry
under different box pressures (0, 50, 100, and 150 mmHg). In the range of
positive P, we found that the compliance of the proximal LAD artery in
situ (4.85 ± 3.8 x 10–3
mm2/mmHg) is smaller than that of the same artery in vitro (16.5
± 6 x 10–3 mm2/mmHg;
P = 0.009). Hence, the myocardium restricts the compliance of the
epicardial artery under distension. In the negative P range, the LAD
artery does not collapse, whereas the same vessel readily collapses when
tested in vitro. Hence, we conclude that myocardial tethering prevents
collapse of large blood vessel under compression.
digital subtraction angiography; video densitometry; mechanical properties; mechanics; tethering
This article has been cited by other articles:
|
|
 |
|
  Y. Liu, W. Zhang, and G. S. Kassab Effects of myocardial constraint on the passive mechanical behaviors of the coronary vessel wall Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H514 - H523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Liu, C. Dang, M. Garcia, H. Gregersen, and G. S. Kassab Surrounding tissues affect the passive mechanics of the vessel wall: theory and experiment Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3290 - H3300. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Zhang, Y. Liu, and G. S. Kassab Flow-induced shear strain in intima of porcine coronary arteries J Appl Physiol, August 1, 2007; 103(2): 587 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Westerhof, C. Boer, R. R. Lamberts, and P. Sipkema Cross-talk between cardiac muscle and coronary vasculature. Physiol Rev, October 1, 2006; 86(4): 1263 - 1308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Choy, Q. Dang, S. Molloi, and G. S. Kassab Nonuniformity of axial and circumferential remodeling of large coronary veins in response to ligation Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1558 - H1565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Kassab Scaling laws of vascular trees: of form and function Am J Physiol Heart Circ Physiol, February 1, 2006; 290(2): H894 - H903. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X Lu and G. S Kassab Nitric oxide is significantly reduced in ex vivo porcine arteries during reverse flow because of increased superoxide production J. Physiol., December 1, 2004; 561(2): 575 - 582. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
