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CO₂-dependent components of sinus arrhythmia from the start of breath holding in humans

¹School of Sport and Exercise Sciences and ²Department of Anaesthesia and Intensive Care, University of Birmingham, Birmingham B15 2TT, United Kingdom

Submitted 17 December 2002 ; accepted in final form 21 April 2003

A substantial portion of sinus arrhythmia in conscious humans appears to be caused by the CO₂-dependent central respiratory rhythm. Under some circumstances, therefore, sinus arrhythmia might indicate the presence of the central respiratory rhythm. Humans can voluntarily modify their central respiratory rhythm (e.g., by pacing breathing or by delaying or advancing breaths), but it is not clear what happens to it from the start of breath holding. In this study, we show that sinus arrhythmia persists from the start of breath holds prolonged by preoxygenation. We also show that some of the frequency components of sinus arrhythmia start within each subject's eupneic frequency range and change when end-tidal PCO₂ is lowered or raised, as we would expect if the central respiratory rhythm continues from the start of breath holding. We discuss whether sinus arrhythmia can indicate if the central respiratory rhythm continues from the start of breath holding.

carbon dioxide

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