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Am J Physiol Heart Circ Physiol 285: H1294-H1302, 2003. First published January 9, 2003; doi:10.1152/ajpheart.00651.2002
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Dietary n-3 PUFAs affect the blood pressure rise and cardiac impairments in a hyperinsulinemia rat model in vivo

Delphine Rousseau,1 Cécile Héliès-Toussaint,1 Daniel Moreau,2 Daniel Raederstorff,3 and Alain Grynberg1

1Lipides Membranaires et Fonctions Cardiovasculaires, Institut National de la Recherche Agronomique-UR1154, Faculté de Pharmacie, Université Paris-Sud, 92290 Châtenay-Malabry;2Laboratory of Experimental Cardiovascular Pathophysiology and Pharmacology, Faculté de Médecine, 21033 Dijon, France; and 3Department VFHF, F. Hoffmann-La Roche, 4070 Basel, Switzerland

Submitted 25 July 2002 ; accepted in final form 26 December 2002

The cardiovascular consequences of eicosapentaenoic acid (EPA)- and docosahexaenoic acid (DHA)-specific intake were evaluated in vivo in a hyperinsulinemia (HI) model induced by dietary fructose intake. Wistar rats were fed a diet containing (or not for control) either EPA or DHA. The rise in blood pressure (BP), heart rate, and ECG were continuously monitored using an intra-abdominal telemetry system. The myocardial phospholipid fatty acid profile was significantly affected by DHA intake but less by EPA intake. The data indicated a reduced rise in BP in both DHA and EPA HI groups compared with controls. This result was confirmed by tail-cuff measurement after 5 wk [133.3 ± 1.67 and 142.5 ± 1.12 mmHg in n-3 polyunsaturated fatty acid (PUFA) and control groups, respectively], whereas n-3 PUFA did not affect BP in non-HI rats (116.3 ± 3.33 mmHg). The heart rate was lower in the HI DHA group than in the other two dietary HI groups. Moreover, DHA induced a significantly shorter QT interval. It is concluded that the cardioactive component of fish oils is DHA through a mechanism that may involve the cardiac adrenergic system.

hypertension; nutrition; prevention; telemetry; heart


Address for reprint requests and other correspondence: A. Grynberg, Institut National de la Recherche Agronomique-UR1154, Lipides Membranaires et Fonctions Cardiovasculaires, Faculté de Pharmacie, Université Paris-Sud, 5 rue Jean Baptiste Clément, 92290 Châtenay-Malabry Cedex, France (E-mail: grynberg{at}jouy.inra.fr).




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