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This Article Full Text Full Text (PDF) All Versions of this Article: 285/3/H1303    most recent 00933.2001v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (8) Citing Articles via Google Scholar Google Scholar Articles by Kellen, M. R. Articles by Bassingthwaighte, J. B. Search for Related Content PubMed PubMed Citation Articles by Kellen, M. R. Articles by Bassingthwaighte, J. B.

An integrative model of coupled water and solute exchange in the heart

Department of Bioengineering, University of Washington, Seattle, Washington 98195

Submitted 1 November 2001 ; accepted in final form 6 August 2002

Physiologists have devised many models for interpreting water and solute exchange data in whole organs, but the models have typically neglected key aspects of the underlying physiology to present the simplest possible model for a given experimental situation. We have developed a physiologically realistic model of microcirculatory water and solute exchange and applied it to diverse observations of water and solute exchange in the heart. Model simulations are consistent with the results of osmotic weight transient, tracer indicator dilution, and steady-state lymph sampling experiments. The key model features that permit this unification are the use of an axially distributed blood-tissue exchange region, inclusion of a lymphatic drain in the interstitium, and the independent computation of transcapillary solute and solvent fluxes through three different pathways.

microcirculation; capillary permeability; osmotic transient; lymph; multiple-indicator dilution

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