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Am J Physiol Heart Circ Physiol 285: H974-H982, 2003. First published April 24, 2003; doi:10.1152/ajpheart.01090.2002
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Weight loss improves neurovascular and muscle metaboreflex control in obesity

Ivani Credidio Trombetta,1 Luciana T. Batalha,2 Maria Urbana P. B. Rondon,1 Mateus Camaroti Laterza,1 Fátima H. S. Kuniyoshi,1 Márcia M. G. Gowdak,1 Antonio Carlos P. Barretto,1 Alfredo Halpern,2 Sandra M. F. Villares,2 and Carlos Eduardo Negrão1,3

1Heart Institute (InCor), Medical School, 2Department of Endocrinology, and 3School of Physical Education and Sports, University of São Paulo, São Paulo, SP CEP 05403-000, Brazil

Submitted 16 December 2002 ; accepted in final form 21 April 2003

We studied the effects of a hypocaloric diet (D, n = 24, age: 32.2 ± 1.4 yr, body mass index: 34.7 ± 0.5 kg/m2) and a hypocaloric diet associated with exercise training (D + T, n = 25, age: 32.3 ± 1.3 yr, body mass index: 32.9 ± 0.4 kg/m2) on muscle metaboreflex control, muscle sympathetic nerve activity (MSNA, microneurography), blood pressure, and forearm blood flow (plethysmography) levels during handgrip exercise at 10% and 30% of maximal voluntary contraction in normotensive obese women. An additional 10 women matched by age and body mass index were studied as a nonadherent group. D or D + T significantly decreased body mass index. D or D + T significantly decreased resting MSNA (bursts/100 heartbeats). The absolute levels of MSNA were significantly lower throughout 10% and 30% exercise after D or D + T, although no change was found in the magnitude of response of MSNA. D + T, but not D, significantly increased resting forearm vascular conductance. D + T significantly increased the magnitude of the response of forearm vascular conductance during 30% exercise. D or D + T significantly increased MSNA levels during posthandgrip circulatory arrest when muscle metaboreflex is isolated. In conclusion, weight loss improves muscle metaboreflex control in obese women. Weight loss reduces MSNA, which seems to be centrally mediated. Weight loss by D + T increases forearm vascular conductance at rest and during exercise in obese individuals.

diet; exercise; reflex control


Address for reprint requests and other correspondence: C. E. Negrão, Instituto do Coração-(InCor), Unidade de Reabilitação Cardiovascular e Fisiologia do Exercício, Av. Dr. Enéas de Carvalho Aguiar, 44, Cerqueira César, São Paulo, SP CEP 05403-000, Brazil (E-mail: cndnegrao{at}incor.usp.br).




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