HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 285/5/H1849    most recent 00384.2002v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (8) Citing Articles via Google Scholar Google Scholar Articles by Miller, C. E. Articles by Sedmera, D. Search for Related Content PubMed PubMed Citation Articles by Miller, C. E. Articles by Sedmera, D.

Pressure overload alters stress-strain properties of the developing chick heart

¹Division of Pediatric Cardiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; and ²Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425

Submitted 9 May 2002 ; accepted in final form 2 July 2003

As a first step in investigating a control mechanism regulating stress and/or strain in the embryonic heart, this study tests the hypothesis that passive mechanical properties of left ventricular (LV) embryonic myocardium change with chronically increased pressure during the chamber septation period. Conotruncal banding (CTB) created ventricular pressure overload in chicks from Hamburger-Hamilton (HH) stage 21 (HH21) to HH27, HH29, or HH31. LV sections were cyclically stretched while biaxial strains and force were measured. Wall architecture was assessed with scanning electron microscopy. In controls, porosity-adjusted stress-strain relations decreased significantly from HH27 to HH31. CTB at HH21 resulted in significantly stiffer stress-strain relations by HH27, with larger increases at HH29 and HH31, and nearly constant wall thickness. Strain patterns, hysteresis, and loading-curve convergence showed few differences after CTB. Trabecular extent decreased with age, but neither extent nor porosity changed significantly after CTB. The stiffened stress-strain relations and constant wall thickness suggest that mechanical load may play a regulatory role in this response.

cardiac development; trabeculae; left ventricle

This article has been cited by other articles:

				B. C. W. Groenendijk, K. Van der Heiden, B. P. Hierck, and R. E. Poelmann The Role of Shear Stress on ET-1, KLF2, and NOS-3 Expression in the Developing Cardiovascular System of Chicken Embryos in a Venous Ligation Model Physiology, December 1, 2007; 22(6): 380 - 389. [Abstract] [Full Text] [PDF]

				K. Tobita, L. J. Liu, A. M. Janczewski, J. P. Tinney, J. M. Nonemaker, S. Augustine, D. B. Stolz, S. G. Shroff, and B. B. Keller Engineered early embryonic cardiac tissue retains proliferative and contractile properties of developing embryonic myocardium Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1829 - H1837. [Abstract] [Full Text] [PDF]

				J. L. Lucitti, R. Visconti, J. Novak, and B. B. Keller Increased arterial load alters aortic structural and functional properties during embryogenesis Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1919 - H1926. [Abstract] [Full Text] [PDF]

				J. L. Lucitti, K. Tobita, and B. B. Keller Arterial hemodynamics and mechanical properties after circulatory intervention in the chick embryo J. Exp. Biol., May 15, 2005; 208(10): 1877 - 1885. [Abstract] [Full Text] [PDF]