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INNOVATIVE METHODOLOGY

Evaluation of a new fiber-optic pressure recording system for cardiovascular measurements in mice

¹Institute for Experimental Medical Research, University of Oslo, and ²Department of Cardiothoracic Surgery, Ullevål University Hospital, 0407 Oslo, Norway

Submitted 20 December 2002 ; accepted in final form 23 June 2003

We have tested a new fiber-optic pressure recording system, Samba, with a thin fiber [outer diameter (OD) = 0.25 mm] and a pressure sensor (length and OD = 0.42 mm) attached to the end. The accuracy of the system tested in vitro was good, with a coefficient of variation of 2.54% at 100 mmHg. The drift was <0.45 mmHg/h, and the temperature sensitivity was 0.07 mmHg/1°C between 22 and 37°C. The frequency response characteristics were similar to a 1.4-Fr Millar catheter (0–200 Hz). Introduction of the Samba sensor from the right carotid artery into the left ventricle in six mice caused no drop in mean aortic pressure, whereas introduction of a 1.4-Fr Millar catheter (OD = 0.47 mm; n = 6) caused a pressure drop from 91.6 ± 9.2 to 65.1 ± 6.2 mmHg; P < 0.05. Thus the Samba sensor system may represent a new alternative to assess hemodynamic variables in the murine cardiovascular system.

catheter size; fiber optics; aortic pressure

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