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Am J Physiol Heart Circ Physiol 285: H2663-H2669, 2003. First published July 17, 2003; doi:10.1152/ajpheart.00128.2003
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A synergistic effect of albumin and fibrinogen on immunoglobulin-induced red blood cell aggregation

Ronen Ben-Ami,1 Gershon Barshtein,4 Tamar Mardi,1 Varda Deutch,2 Ori Elkayam,3 Saul Yedgar,4 and Shlomo Berliner1

Departments of 1Internal Medicine D, 2Hematology, and 3Rheumatology, Sourasky Medical Center, Tel Aviv 64239; and 4Department of Biochemistry, Hadassah Medical School, Hebrew University, Jerusalem 91120, Israel

Submitted 23 February 2003 ; accepted in final form 3 July 2003

Therapeutic administration of immunoglobulins (Ig) has the potential to precipitate thrombotic events. This phenomenon may be explained by red blood cell (RBC) aggregation, which can be potentiated by Ig. The contribution of plasma albumin and fibrinogen to Ig-induced RBC aggregation is unclear. We examined RBC aggregation in three settings: 1) patients receiving therapeutic infusions of Ig; 2) patients receiving plasma supplemented in vitro with Ig; and 3) patients receiving RBC suspensions in standard buffer with varying concentrations of albumin, Ig, and fibrinogen. Ig infusion augmented aggregation of RBCs from patients with normal or high plasma levels of albumin but decreased aggregation in those with lower plasma albumin concentrations. In vitro, RBC aggregation was significantly increased only when all three components, fibrinogen, albumin, and Ig, were present at or above normal concentrations in the suspension but was unaffected when any one of the components was absent from the suspension. Our results suggest a three-way interaction among fibrinogen, Ig, and albumin that synergistically induces RBC aggregation in plasma. Understanding these interactions may help predict clinically important phenomena related to RBC aggregation, such as thrombotic complications of Ig infusion.

hemorheology; thrombosis; adverse effects


Address for reprint requests and other correspondence: S. Yedgar, Dept. of Biochemistry, Hadassah Medical School, Hebrew Univ., Jerusalem 91120, Israel (E-mail: yedgar{at}md2.huji.ac.il).




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