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Am J Physiol Heart Circ Physiol 286: H889-H894, 2004. First published October 23, 2003; doi:10.1152/ajpheart.00967.2001
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Acute and specific collagen type I degradation increases diastolic and developed tension in perfused rat papillary muscle

Regis R. Lamberts,1 Maurice J. J. M. F. Willemsen,1 Néstor G. Pérez,2 Pieter Sipkema,1 and Nico Westerhof1

1Laboratory for Physiology, Institute for Cardiovascular Research, Vrije Universiteit Medical Center, 1081 BT Amsterdam, The Netherlands; and 2Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Buenos Aires, Argentina 1900

Submitted 5 November 2001 ; accepted in final form 17 October 2003

Collagen degradation is suggested to be responsible for long-term contractile dysfunction in different cardiomyopathies, but the effects of acute and specific collagen type I removal (main type in the heart muscle) on tension have not been studied. We determined the diastolic and developed tension length relations in isometric contracting perfused rat papillary muscles (perfusion pressure 60 cmH2O) before and after acute and specific removal of small collagen struts with the use of purified collagenase type I. At 95% of the maximal length (95%Lmax), diastolic tension increased 20.4 ± 8.1% (P < 0.05, n = 6) and developed tension increased 15.0 ± 6.7% after collagenase treatment compared with time controls. Treatment increased the diastolic muscle diameter by 7.1 ± 3.4% at 95%Lmax, whereas the change in diameter due to contraction was not changed. Diastolic coronary flow and normalized coronary arterial flow impediment did not change after collagenase treatment. Electron microscopy revealed that the number of small collagen struts, interconnecting myocytes, and capillaries was reduced to ~32% after treatment. We conclude that removal of the small collagen struts by acute and specific collagen type I degradation increases diastolic and developed tension in perfused papillary muscle. We suggest that diastolic tension is increased due to edema, whereas developed tension is increased because the removal of the struts poses a lower lateral load on the cardiac myocytes, allowing more myocyte thickening.

cardiac contraction; coronary flow; collagen struts; edema; flow impediment


Address for reprint requests and other correspondence: R. R. Lamberts, Laboratory for Physiology, ICaR-VU, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands (E-mail: lamberts{at}physiol.med.vu.nl).




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