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Pattern differences between distributions of microregional myocardial flows in crystalloid- and blood-perfused rat hearts

¹Department of Medical Engineering and Systems Cardiology, Kawasaki Medical School, Kurashiki 701-0192; ²Department of Mechanical Science and Bioengineering, Osaka University Graduate School of Engineering Science, Toyonaka 560-8531; ³Life and Environmental Science Division, Japan Synchrotron Radiation Research Institute, Mikazuki 679-5198; and ⁴Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, Japan

Submitted 6 February 2003 ; accepted in final form 10 December 2003

Regional myocardial flow distributions in Langendorff rat hearts under Tyrode and blood perfusion were assessed by tracer digital radiography (100-µm resolution). Flow distributions during baseline and maximal hyperemia following a 60-s flow cessation were evaluated by the coefficient of variation of regional flows (CV; related to global flow heterogeneity) and the correlation between adjacent regional flows (CA; inversely related to local flow randomness). These values were obtained for the original images (64² pixels) and for coarse-grained images (32², 16², and 8² blocks of nearby pixels). At a given point in time during baseline, both CV and CA were higher in blood (n = 7) than in Tyrode perfusion (n = 7) over all pixel aggregates (P < 0.05, two-way ANOVA). During the maximal hyperemia, CV and CA were still significantly higher in blood (n = 7) than in Tyrode perfusion (n = 7); however, these values decreased substantially in blood perfusion and the CV and CA differences became smaller than those at baseline accordingly. During basal blood perfusion, the 60-s average flow distribution (n = 7) showed a smaller CV and CA than those at a given point in time (P < 0.05, two-way ANOVA). Coronary flow reserve was significantly higher in blood than in Tyrode perfusion. In conclusion, the flow heterogeneity and the local flow similarity are both higher in blood than in Tyrode perfusion, probably due to the different degree of coronary tone preservation and the presence or absence of blood corpuscles. Under blood perfusion, temporal flow fluctuations over 60-s order are largely involved in shaping microregional flow distributions.

regional myocardial perfusion; O₂ carrying capacity; blood corpuscles; coronary tone; tracer digital radiography

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