AJP - Heart Journal of Neurophysiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 286: H1590-H1595, 2004. First published December 18, 2003; doi:10.1152/ajpheart.01100.2001
0363-6135/04 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
286/4/H1590    most recent
01100.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (7)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sun, Y.-H.
Right arrow Articles by Tyberg, J. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sun, Y.-H.
Right arrow Articles by Tyberg, J. V.

Effects of left ventricular contractility and coronary vascular resistance on coronary dynamics

Yi-Hui Sun,1 Todd J. Anderson,1 Kim H. Parker,2 and John V. Tyberg1

1Department of Medicine and Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada T2N 4N1; and 2Physiological Flow Studies Group, Department of Biological and Medical Systems, Imperial College of Science, Technology, and Medicine, London SW7 2AZ, United Kingdom

Submitted 14 December 2001 ; accepted in final form 9 November 2003

Wave-intensity analysis, which separates upstream from downstream events and defines their interaction, has been used to study the effects of changes in left ventricular (LV) contractility (Emax) and left circumflex coronary artery resistance (RLCx) on the coronary systolic flow impediment (CSFI). In 10 anesthetized, open-chest dogs, we measured coronary, aortic, and LV pressures, coronary velocity (Flowire), and flow. Emax was increased by paired pacing and RLCx was modulated by intracoronary infusions of vasodilators (adenosine and nitroglycerin) and a vasoconstrictor (phenylephrine). When both Emax and RLCx were varied, CSFI and the energy of the backward-going compression wave (IW–) were greatest at the highest levels of Emax and the lowest levels of RLCx. IW– was proportional to the CSFI. We conclude that contractility and coronary resistance change CSFI by modulating the backward-going compression wave.

wave intensity analysis; coronary flow impediment


Address for reprint requests and other correspondence: J. V. Tyberg, Univ. of Calgary Health Sciences Centre, 3330 Hospital Dr. NW, Calgary, Alberta, Canada T2N 4N1 (E-mail: jtyberg{at}ucalgary.ca).




This article has been cited by other articles:


Home page
 Phil Trans R Soc AHome page
J. Spaan, C. Kolyva, J. van den Wijngaard, R. ter Wee, P. van Horssen, J. Piek, and M. Siebes
Coronary structure and perfusion in health and disease
Phil Trans R Soc A, September 13, 2008; 366(1878): 3137 - 3153.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
N. Hadjiloizou, J. E. Davies, I. S. Malik, J. Aguado-Sierra, K. Willson, R. A. Foale, K. H. Parker, A. D. Hughes, D. P. Francis, and J. Mayet
Differences in cardiac microcirculatory wave patterns between the proximal left mainstem and proximal right coronary artery
Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H1198 - H1205.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
N. Westerhof, C. Boer, R. R. Lamberts, and P. Sipkema
Cross-talk between cardiac muscle and coronary vasculature.
Physiol Rev, October 1, 2006; 86(4): 1263 - 1308.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2004 by the American Physiological Society.