| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of 1Physiology and 2Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614
Submitted 22 September 2003 ; accepted in final form 10 December 2003
Antibody-coated microprobes were inserted into the thoracic (T3–4) spinal cord in urethane-anesthetized Sprague-Dawley rats to detect the differences in the release of immunoreactive substance P-like (irSP) substances in response to differential activation of cardiac nociceptive sensory neurons (CNAN). CNAN were stimulated either by intrapericardial infusion of an inflammatory ischemic exudate solution (IES) containing algogenic substances (i.e., 10 mM each of adenosine, bradykinin, prostaglandin E2, and 5-hydroxytryptamine), or by transient occlusion of the left anterior descending coronary artery (CoAO). There was widespread basal release of irSP from the thoracic spinal cord. Stimulation of the CNAN by IES did not alter the pattern of release of irSP. Conversely, CoAO augmented the release of irSP from T3–4 spinal segments from laminae I–VII. This CoAO-induced irSP release was eliminated after thoracic dorsal rhizotomy. These results indicate that heterogeneous activation of cardiac afferents, as with focal coronary artery occlusion, represents an optimum input for activation of the cardiac neuronal hierarchy and for the resultant perception of angina. Excessive stimulation of cardiac nociceptive afferent neurons elicited during regional coronary artery occlusion involves the release of SP in the thoracic spinal cord and suggests that local spinal cord release of SP may be involved in the neural signaling of angina.
antibody-coated microprobes; coronary artery occlusion; algogenic substances; angina; cardiac nervous system
This article has been cited by other articles:
|
|
 |
|
  X. Ding, F. Hua, K. Sutherly, J. L. Ardell, and C. A. Williams C2 spinal cord stimulation induces dynorphin release from rat T4 spinal cord: potential modulation of myocardial ischemia-sensitive neurons Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2008; 295(5): R1519 - R1528. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Zhong and D. H. Wang N-oleoyldopamine, a novel endogenous capsaicin-like lipid, protects the heart against ischemia-reperfusion injury via activation of TRPV1 Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H728 - H735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Ding, J. L. Ardell, F. Hua, R. J. McAuley, K. Sutherly, J. J Daniel, and C. A. Williams Modulation of cardiac ischemia-sensitive afferent neuron signaling by preemptive C2 spinal cord stimulation: effect on substance P release from rat spinal cord Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R93 - R101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Zhong and D. H. Wang TRPV1 gene knockout impairs preconditioning protection against myocardial injury in isolated perfused hearts in mice Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1791 - H1798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Hua, J. L. Ardell, and C. A. Williams Left vagal stimulation induces dynorphin release and suppresses substance P release from the rat thoracic spinal cord during cardiac ischemia Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2004; 287(6): R1468 - R1477. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Hua, T. Harrison, C. Qin, A. Reifsteck, B. Ricketts, C. Carnel, and C. A. Williams c-Fos expression in rat brain stem and spinal cord in response to activation of cardiac ischemia-sensitive afferent neurons and electrostimulatory modulation Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2728 - H2738. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
