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This Article Full Text Full Text (PDF) All Versions of this Article: 287/1/H243    most recent 01125.2003v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (14) Citing Articles via Google Scholar Google Scholar Articles by Carlsson, M. Articles by Arheden, H. Search for Related Content PubMed PubMed Citation Articles by Carlsson, M. Articles by Arheden, H.

Total heart volume variation throughout the cardiac cycle in humans

Departments of ¹Clinical Physiology, ²Radiology, and ³Radiophysics, Lund University Hospital, Lund SE-22185; and ⁴Inovacor, Stockholm SE-18592, Sweden

Submitted 25 November 2003 ; accepted in final form 5 March 2004

Variations in total heart volume (atria plus ventricles) during a cardiac cycle affect efficiency of cardiac pumping. The goals of this study were to confirm the presence, extent, and contributors of total heart volume variation during the cardiac cycle in healthy volunteers with the use of MRI. Eight healthy volunteers were examined by MRI at rest. Changes in total cardiac volume throughout the cardiac cycle were calculated using the following methods: 1) planimetry derived from gradient-echo cine images and 2) flow-sensitive sequences to quantify flow in all vessels leading to and from the heart. The maximum total heart volume diminished during systole by 8.2 ± 0.8% (SEM, range 4.8–10.6%) measured by method 1 and 8.8 ± 1.0% (SEM, range 5.6–11.8%) by method 2 with good agreement between the methods [difference according to Bland-Altman analysis –0.6% ± 1.0% (SD), intraclass correlation coefficient = 0.999]. This decrease in volume is predominantly explained by variation at the midcardiac level at the widest diameter of the heart with a left-sided predominance. In the short axis of the heart, the change of slice volume was proportional to the end-diastolic slice volume. The present study has confirmed the presence of total heart volume variation that predominantly occurs in the region of atrioventricular plane movement and on the left side. The total heart volume variation may relate to the efficiency of energy use by the heart to minimize displacement of surrounding tissue while accounting for the energy required to draw blood into the atria during ventricular systole.

magnetic resonance imaging; left ventricle; output

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