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Cardiac sympathetic nerve stimulation does not attenuate dynamic vagal control of heart rate via -adrenergic mechanism

¹Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Osaka 565-8565; ²Japan Association for the Advancement of Medical Equipment, Tokyo 105-0013; and ³The Organization for Pharmaceutical Safety and Research, Tokyo 100-0013, Japan

Submitted 7 August 2003 ; accepted in final form 6 March 2004

Complex sympathovagal interactions govern heart rate (HR). Activation of the postjunctional -adrenergic receptors on the sinus nodal cells augments the HR response to vagal stimulation, whereas exogenous activation of the presynaptic -adrenergic receptors on the vagal nerve terminals attenuates vagal control of HR. Whether the -adrenergic mechanism associated with cardiac postganglionic sympathetic nerve activation plays a significant role in modulation of the dynamic vagal control of HR remains unknown. The right vagal nerve was stimulated in seven anesthetized rabbits that had undergone sinoaortic denervation and vagotomy according to a binary white-noise signal (0–10 Hz) for 10 min; subsequently, the transfer function from vagal stimulation to HR was estimated. The effects of -adrenergic blockade with propranolol (1 mg/kg iv) and the combined effects of -adrenergic blockade and tonic cardiac sympathetic nerve stimulation at 5 Hz were examined. The transfer function from vagal stimulation to HR approximated a first-order, low-pass filter with pure delay. -Adrenergic blockade decreased the dynamic gain from 6.0 ± 0.4 to 3.7 ± 0.6 beats·min^–1·Hz^–1 (P < 0.01) with no alteration of the corner frequency or pure delay. Under -adrenergic blockade conditions, tonic sympathetic stimulation did not further change the dynamic gain (3.8 ± 0.5 beats·min^–1·Hz^–1). In conclusion, cardiac postganglionic sympathetic nerve stimulation did not affect the dynamic HR response to vagal stimulation via the -adrenergic mechanism.

systems analysis; transfer function; -adrenergic blockade; rabbits; sympathovagal interaction

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