HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 287/4/H1501    most recent 00227.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (39) Citing Articles via Google Scholar Google Scholar Articles by Carswell, H.V.O. Articles by Horsburgh, K.J. Search for Related Content PubMed PubMed Citation Articles by Carswell, H.V.O. Articles by Horsburgh, K.J.

Neuroprotection by a selective estrogen receptor agonist in a mouse model of global ischemia

¹Wellcome Surgical Institute and Hugh Fraser Neuroscience Laboratories, Division of Clinical Neuroscience, University of Glasgow, Glasgow, G61 1QH; and ²Division of Neuroscience, University of Edinburgh, Edinburgh, EH8 9JZ United Kingdom

Submitted 18 March 2004 ; accepted in final form 12 May 2004

The present study employs selective estrogen receptor (ER) agonists to determine whether 17-estradiol-induced neuroprotection in global ischemia is receptor mediated and, if so, which subtype of receptor (ER or ER) is predominantly responsible. Halothane-anesthetized female C57Bl/6J mice were ovariectomized, and osmotic minipumps containing ER agonist diarylpropiolnitrile (DPN) (8 mg·kg^–1·day^–1, n = 12) or vehicle (50% DMSO in 0.9% saline) (n = 9) or ER agonist propyl pyrazole triol (PPT) (2 mg·kg^–1·day^–1, n = 13) or vehicle (50% DMSO in 0.9% saline) (n = 10) were implanted subcutaneously. One week later transient global ischemia was induced by bilateral carotid artery occlusion under halothane anesthesia, and the mice were perfusion fixed 72 h later. ER agonist DPN significantly reduced ischemic damage by 70% in the caudate nucleus and 55% in the CA1 region compared with vehicle controls (P < 0.05, Mann-Whitney U-statistic). In contrast, pretreatment with the ER agonist PPT had no effect on the extent of neuronal damage compared with controls. The data indicate a significant estrogen receptor-mediated neuroprotection in a global cerebral ischemia model involving ER.

estrogen receptor subtypes; neuroprotection; diarylpropiolnitrile; propyl pyrazole triol

This article has been cited by other articles:

				J. A. Arreguin-Arevalo, T. L. Davis, and T. M. Nett Differential Modulation of Gonadotropin Secretion by Selective Estrogen Receptor 1 and Estrogen Receptor 2 Agonists in Ovariectomized Ewes Biol Reprod, August 1, 2007; 77(2): 320 - 328. [Abstract] [Full Text] [PDF]

				F. Hildebrand, W. J. Hubbard, M. A. Choudhry, B. M. Thobe, H.-C. Pape, and I. H. Chaudry Are the protective effects of 17{beta}-estradiol on splenic macrophages and splenocytes after trauma-hemorrhage mediated via estrogen-receptor (ER)-{alpha} or ER-{beta}? J. Leukoc. Biol., June 1, 2006; 79(6): 1173 - 1180. [Abstract] [Full Text] [PDF]

				D. A. Schreihofer, K. D. Do, and A. M. Schreihofer High-soy diet decreases infarct size after permanent middle cerebral artery occlusion in female rats Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R103 - R108. [Abstract] [Full Text] [PDF]