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Am J Physiol Heart Circ Physiol 287: H1887-H1888, 2004; doi:10.1152/classicessays.00012.2004
0363-6135/04 $5.00

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EDITORIAL FOCUS

ESSAYS ON APS CLASSIC PAPERS

Microvascular permeability, ultrafiltration, and restricted diffusion

Division of Biomedical Sciences, Imperial College, London SW7 2AZ, United Kingdom

ABSTRACT

This essay looks at the historical significance of two APS classic papers that are freely available online:

Pappenheimer JR and Soto-Rivera A. Effective osmotic pressure of the plasma proteins and other quantities associated with the capillary circulation in the hindlimbs of cats and dogs. Am J Physiol 152: 471–491, 1948 (http://ajplegacy.physiology.org/cgi/reprint/152/3/471).

Pappenheimer JR, Renkin EM, and Borrero LM. Filtration, diffusion and molecular sieving through peripheral capillary membranes: a contribution to the pore theory of capillary permeability. Am J Physiol 167: 13–46, 1951 (http://ajplegacy.physiology.org/cgi/reprint/167/1/13).