HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 287/5/H1913    most recent 00565.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (10) Citing Articles via Google Scholar Google Scholar Articles by Merrill, G. F. Articles by Golfetti, R. Search for Related Content PubMed PubMed Citation Articles by Merrill, G. F. Articles by Golfetti, R.

TRANSLATIONAL PHYSIOLOGY

Acetaminophen and myocardial infarction in dogs

Department of Cell Biology and Neurosciences, Division of Life Sciences, Rutgers University, Piscataway, New Jersey 08854

Submitted 10 June 2004 ; accepted in final form 14 July 2004

The hypothesis that acetaminophen can reduce necrosis during myocardial infarction was tested in male dogs. Two groups were studied: vehicle- (n = 10) and acetaminophen-treated (n = 10) dogs. All dogs were obtained from the same vendor, and there were no significant differences in their ages (18 ± 2 mo), weights (24 ± 1 kg), or housing conditions. Selected physiological data, e.g., coronary blood flow, nonspecific collateral flow, epicardial temperature, heart rate, systemic mean arterial pressure, left ventricular developed pressure, the maximal first derivative of left ventricular developed pressure, blood gases, and pH, were collected at baseline and during regional myocardial ischemia and reperfusion. There were no significant differences in coronary blood flow, nonspecific collateral flow, epicardial temperature, heart rate, systemic mean arterial pressure, or blood gases and pH between the two groups at any of the three time intervals, even though there was a trend toward improved function in the presence of acetaminophen. Infarct size, the main objective of the investigation, was markedly and significantly reduced by acetaminophen. For example, when expressed as a percentage of ventricular wet weight, infarct size was 8 ± 1 versus 3 ± 1%(P < 0.05) in vehicle- and acetaminophen-treated hearts, respectively. When infarct size was expressed as percentage of the area at risk, it was 35 ± 3 versus 13 ± 2% (P < 0.05) in vehicle- and acetaminophen-treated groups, respectively. When area at risk was expressed as percentage of total ventricular mass, there were no differences in the two groups. Results reveal that the recently reported cardioprotective properties of acetaminophen in vitro can now be extended to the in vivo arena. They suggest that it is necessary to add acetaminophen to the growing list of pharmaceuticals that possess cardioprotective efficacy in mammals.

canine myocardium; heart disease; area at risk; electron microscopy

This article has been cited by other articles:

				N. M. Hadzimichalis, S. S. Baliga, R. Golfetti, K. M. Jaques, B. L. Firestein, and G. F. Merrill Acetaminophen-mediated cardioprotection via inhibition of the mitochondrial permeability transition pore-induced apoptotic pathway Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3348 - H3355. [Abstract] [Full Text] [PDF]

				G. F. Merrill, J. H. Merrill, R. Golfetti, K. M. Jaques, N. S. Hadzimichalis, S. S. Baliga, and T. H. Rork Antiarrhythmic Properties of Acetaminophen in the Dog Experimental Biology and Medicine, October 1, 2007; 232(9): 1245 - 1252. [Abstract] [Full Text] [PDF]

				B. G. Leshnower, H. Sakamoto, A. Zeeshan, L. M. Parish, R. Hinmon, T. Plappert, B. M. Jackson, J. H. Gorman III, and R. C. Gorman Role of acetaminophen in acute myocardial infarction Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2424 - H2431. [Abstract] [Full Text] [PDF]

				A. H. Aletras, G. S. Tilak, A. Natanzon, L.-Y. Hsu, F. M. Gonzalez, R. F. Hoyt Jr, and A. E. Arai Retrospective Determination of the Area at Risk for Reperfused Acute Myocardial Infarction With T2-Weighted Cardiac Magnetic Resonance Imaging: Histopathological and Displacement Encoding With Stimulated Echoes (DENSE) Functional Validations Circulation, April 18, 2006; 113(15): 1865 - 1870. [Abstract] [Full Text] [PDF]

				Y. Z. Zhu, C. L. Chong, S. C. Chuah, S. H. Huang, H. S. Nai, H. T. Tong, M. Whiteman, and P. K. Moore Cardioprotective effects of nitroparacetamol and paracetamol in acute phase of myocardial infarction in experimental rats Am J Physiol Heart Circ Physiol, February 1, 2006; 290(2): H517 - H524. [Abstract] [Full Text] [PDF]