HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 287/5/H2035    most recent 00372.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Lavrentyev, E. N. Articles by Cook, G. A. Search for Related Content PubMed PubMed Citation Articles by Lavrentyev, E. N. Articles by Cook, G. A.

Expression of genes participating in regulation of fatty acid and glucose utilization and energy metabolism in developing rat hearts

Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163

Submitted 19 April 2004 ; accepted in final form 22 June 2004

The heart is a unique organ that can use several fuels for energy production. During development, the heart undergoes changes in fuel supply, and it must be able to respond to these changes. We have examined changes in the expression of several genes that regulate fuel transport and metabolism in rat hearts during early development. At birth, there was increased expression of fatty acid transporters and enzymes of fatty acid metabolism that allow fatty acids to become the major source of energy for cardiac muscle during the first 2 wk of life. At the same time, expression of genes that control glucose transport and oxidation was downregulated. After 2 wk, expression of genes for glucose uptake and oxidation was increased, and expression of genes for fatty acid uptake and utilization was decreased. Expression of carnitine palmitoyltransferase I (CPT I) isoforms during development was different from published data obtained from rabbit hearts. CPT I and I isoforms were both highly expressed in hearts before birth, and both increased further at birth. Only after the second week did CPT I expression decrease appreciably below the level of CPT I expression. These results represent another example of different expression patterns of CPT I isoforms among various mammalian species. In rats, changes in gene expression followed nutrient availability during development and may render cardiac fatty acid oxidation less sensitive to factors that influence malonyl-CoA content (e.g., fluctuations in glucose concentration) and thereby favor fatty acid oxidation as an energy source for cardiomyocytes in early development.

carnitine palmitoyltransferase; oxidation; translocase; acetyl-CoA

This article has been cited by other articles:

				T. D. Scholz and J. L. Segar Cardiac Metabolism in the Fetus and Newborn NeoReviews, March 1, 2008; 9(3): e109 - e118. [Abstract] [Full Text] [PDF]