| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1Department of Physiology and Biophysics, Case Western Reserve University, and 2Department of Medicine, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106
Submitted 27 April 2004 ; accepted in final form 15 June 2004
The rat infarct model is widely used in heart failure research, but few echocardiographic indexes of left ventricular (LV) function are validated in this model. Accordingly, the objective of this study was to validate a 13-segment LV wall motion score index (WMSI) and the myocardial performance index (MPI) in infarcted rats. Twenty-nine male Wistar rats underwent left coronary artery ligation or sham operation and were evaluated with two-dimensional and Doppler flow echocardiography 8 wk later. After echocardiography, invasive indexes were obtained using a high-fidelity catheter. WMSI and MPI were correlated with the invasive and noninvasive measurements of LV function. WMSI and MPI significantly correlated directly with end-diastolic pressure (r = 0.72 and 0.42 for WMSI and MPI, respectively) and the time constant of isovolumic relaxation (r = 0.68 and 0.48) and inversely with peak rate of rise of LV pressure (+dP/dt; r = –0.68 and –0.50), peak rate of decline in LV pressure (r = –0.57 and –0.44), LV developed pressure (r = –0.58 and –0.42), area fractional shortening (r = –0.85 and –0.53), and cardiac index (r = –0.74 and –0.74). Stepwise linear regression analyses revealed that LV end-diastolic pressure, +dP/dt, area fractional shortening, and cardiac index were independent determinants of WMSI (r = 0.994) and that cardiac index and +dP/dt were independent determinants of MPI (r = 0.781). We conclude that the 13-segment WMSI and MPI are reproducible and correlate strongly with established echocardiographic and invasive indexes of systolic and diastolic function. These findings support the use of WMSI and MPI as indexes of global LV function in the rat infarction model of heart failure.
wall motion score index; myocardial performance index; heart failure; ventricular function; echocardiography
This article has been cited by other articles:
|
|
 |
|
  J. Xu, C. Zhang, and A. Khanna Wideband High-Frequency Echocardiography to Evaluate Myocardial Infarct Size J. Ultrasound Med., November 1, 2009; 28(11): 1527 - 1534. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Maron, D. J. Luther, C. F. Pilati, V. Ohanyan, T. Li, S. Koshy, W. I. Horne, J. G. Meszaros, J. M. Walro, and H. G. Folkesson {beta}-Adrenoceptor stimulation of alveolar fluid clearance is increased in rats with heart failure Am J Physiol Lung Cell Mol Physiol, September 1, 2009; 297(3): L487 - L495. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. T. Cicila, E. E. Morgan, S. J. Lee, P. Farms, S. Yerga-Woolwine, E. J. Toland, R. S. Ramdath, K. Gopalakrishnan, K. Bohman, A. L. Nestor-Kalinoski, et al. Epistatic Genetic Determinants of Blood Pressure and Mortality in a Salt-Sensitive Hypertension Model Hypertension, April 1, 2009; 53(4): 725 - 732. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Rennison, T. A. McElfresh, I. C. Okere, H. V. Patel, A. B. Foster, K. K. Patel, M. S. Stoll, P. E. Minkler, H. Fujioka, B. D. Hoit, et al. Enhanced acyl-CoA dehydrogenase activity is associated with improved mitochondrial and contractile function in heart failure Cardiovasc Res, July 15, 2008; 79(2): 331 - 340. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Kennedy, J. Elkareh, A. Shidyak, A. P. Shapiro, S. Smaili, K. Mutgi, S. Gupta, J. Tian, E. Morgan, S. Khouri, et al. Partial nephrectomy as a model for uremic cardiomyopathy in the mouse Am J Physiol Renal Physiol, February 1, 2008; 294(2): F450 - F454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Duda, K. M. O'Shea, B. Lei, B. R. Barrows, A. M. Azimzadeh, T. E. McElfresh, B. D. Hoit, W. J. Kop, and W. C. Stanley Dietary supplementation with {omega}-3 PUFA increases adiponectin and attenuates ventricular remodeling and dysfunction with pressure overload Cardiovasc Res, November 1, 2007; 76(2): 303 - 310. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Chandler, E. E. Morgan, T. A. McElfresh, T. A. Kung, J. H. Rennison, B. D. Hoit, and M. E. Young Heart failure progression is accelerated following myocardial infarction in type 2 diabetic rats Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1609 - H1616. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Rennison, T. A. McElfresh, I. C. Okere, E. J. Vazquez, H. V. Patel, A. B. Foster, K. K. Patel, Q. Chen, B. D. Hoit, K.-Y. Tserng, et al. High-fat diet postinfarction enhances mitochondrial function and does not exacerbate left ventricular dysfunction Am J Physiol Heart Circ Physiol, March 1, 2007; 292(3): H1498 - H1506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. C. Okere, M. E. Young, T. A. McElfresh, D. J. Chess, V. G. Sharov, H. N. Sabbah, B. D. Hoit, P. Ernsberger, M. P. Chandler, and W. C. Stanley Low Carbohydrate/High-Fat Diet Attenuates Cardiac Hypertrophy, Remodeling, and Altered Gene Expression in Hypertension Hypertension, December 1, 2006; 48(6): 1116 - 1123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. E. Morgan, M. P. Chandler, M. E. Young, T. A. McElfresh, T. A. Kung, J. H. Rennison, K.-Y. Tserng, B. D. Hoit, and W. C. Stanley Dissociation between gene and protein expression of metabolic enzymes in a rodent model of heart failure Eur J Heart Fail, November 1, 2006; 8(7): 687 - 693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. C. Okere, M. P. Chandler, T. A. McElfresh, J. H. Rennison, V. Sharov, H. N. Sabbah, K.-Y. Tserng, B. D. Hoit, P. Ernsberger, M. E. Young, et al. Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin Am J Physiol Heart Circ Physiol, July 1, 2006; 291(1): H38 - H44. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E. Morgan, J. H. Rennison, M. E. Young, T. A. McElfresh, T. A. Kung, K.-Y. Tserng, B. D. Hoit, W. C. Stanley, and M. P. Chandler Effects of chronic activation of peroxisome proliferator-activated receptor-{alpha} or high-fat feeding in a rat infarct model of heart failure Am J Physiol Heart Circ Physiol, May 1, 2006; 290(5): H1899 - H1904. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Jegger, X. Jeanrenaud, M. Nasratullah, P.-G. Chassot, A. Mallik, H. Tevaearai, L. K. von Segesser, P. Segers, and N. Stergiopulos Noninvasive Doppler-derived myocardial performance index in rats with myocardial infarction: validation and correlation by conductance catheter Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1540 - H1548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. R. Mills, N. Mal, F. Forudi, Z. B. Popovic, M. S. Penn, and K. R. Laurita Optical mapping of late myocardial infarction in rats Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1298 - H1306. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
