HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (8) Citing Articles via Google Scholar Google Scholar Articles by Xing, D. Articles by Martins, J. B. Search for Related Content PubMed PubMed Citation Articles by Xing, D. Articles by Martins, J. B.

Triggered activity due to delayed afterdepolarizations in sites of focal origin of ischemic ventricular tachycardia

Division of Cardiovascular Diseases, Department of Internal Medicine, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City, Iowa 52242

Submitted 12 January 2004 ; accepted in final form 25 June 2004

This study for the first time systematically evaluated the site of origin of focal ventricular tachycardia (VT) induced 1–3 h after acute coronary artery ligation in dogs. We determined whether delayed afterdepolarizations (DADs) and triggered activity (TA) are more often recorded from ischemic endocardium excised from focal sites of VT origin. A total of 145 -chloralose-anesthetized dogs were studied: in 54 dogs without inducible VT, normal or ischemic endocardium was investigated in vitro; in 91 dogs, inducible VT was studied by three-dimensional activation mapping, with in vitro study of 51 endocardial foci compared with 40 endocardial ischemic sites not of VT origin. Incidence of DADs (71% vs. 33%, P < 0.05) and TA (32% vs. 11%, P < 0.05) was greater in ischemic than in normal Purkinje tissues. Purkinje sites of origin of focal VT demonstrated the greatest frequency of DADs (92%, P < 0.05) and TA (75%, P < 0.05), with repetitive TA predominating. Similar results were obtained in endocardial sites of origin. Action potentials were mildly depolarized and prolonged in the focal sites of origin. These abnormalities were stable up to 2.5 h of recording. This study demonstrated that DADs and TA may underlie a majority of focal VTs in ischemic endocardium and Purkinje tissue.

ventricles; myocardial infarction; endocardium

This article has been cited by other articles:

				R. Gopinathannair, A. K. Chaudhary, D. Xing, D. Ely, W. Zheng, and J. B. Martins Angiotensin II effects on ischemic focal ventricular tachycardia are predominantly mediated through myocardial AT2 receptor Am J Physiol Heart Circ Physiol, November 1, 2009; 297(5): H1889 - H1898. [Abstract] [Full Text] [PDF]

				P. Stewart, O. V. Aslanidi, D. Noble, P. J. Noble, M. R. Boyett, and H. Zhang Mathematical models of the electrical action potential of Purkinje fibre cells Phil Trans R Soc A, June 13, 2009; 367(1896): 2225 - 2255. [Abstract] [Full Text] [PDF]

				D. J. Dosdall, P. B. Tabereaux, J. J. Kim, G. P. Walcott, J. M. Rogers, C. R. Killingsworth, J. Huang, P. G. Robertson, W. M. Smith, and R. E. Ideker Chemical ablation of the Purkinje system causes early termination and activation rate slowing of long-duration ventricular fibrillation in dogs Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H883 - H889. [Abstract] [Full Text] [PDF]

				K. A. Ellenbogen, J. H. Levine, R. D. Berger, J. P. Daubert, S. L. Winters, E. Greenstein, A. Shalaby, A. Schaechter, H. Subacius, A. Kadish, et al. Are Implantable Cardioverter Defibrillator Shocks a Surrogate for Sudden Cardiac Death in Patients With Nonischemic Cardiomyopathy? Circulation, February 14, 2006; 113(6): 776 - 782. [Abstract] [Full Text] [PDF]