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Theoretical considerations in the dynamic closed-loop baroreflex and autoregulatory control of total peripheral resistance

Harvard-Massachusetts Institute of Technology, Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142

Submitted 2 June 2003 ; accepted in final form 24 June 2004

The most important goal of this study is to enhance our understanding of the crucial functional relationships that determine the behavior of the systemic circulation and its underlying physiological regulatory mechanisms with minimal modeling. To the present day, much has been said about the indirect hydraulic effects of right atrial pressure (P_RA) via cardiac output (CO) on arterial pressure (P_a) through the heart and pulmonary circulation or the direct regulatory effects of P_RA on P_a through the cardiopulmonary baroreflex; however, very little attention has been given to the hydraulic influence that P_RA exerts directly through the systemic circulation. The experimental data reported by Guyton et al. in 1957 demonstrated that steady-state P_RA and the rate at which blood passes through the systemic circulation are locked in a functional relationship independent of any consequence of altered P_RA on cardiac function. With this in mind, we emphasize the analytic algebraic analysis of the systemic circulation composed of arteries, veins, and its underlying physiological regulatory mechanisms of baroreflex and autoregulatory modulation of total peripheral resistance (TPR), where the behavior of the system can be analytically synthesized from an understanding of its minimal elements. As a result of this analysis, we present a novel mathematical method to determine short-term TPR fluctuations, which accounts for the entirety of observed P_a fluctuations, and propose a new cardiovascular system identification method to delineate the actual actions of the physiological mechanisms responsible for the dynamic couplings between CO, P_a, P_RA, and TPR in an individual subject.

autonomic regulation; arterial and cardiopulmonary baroreceptors; local vascular autoregulation; system identification; cardiovascular regulatory physiology

This article has been cited by other articles:

				N. Aljuri, R. Marini, and R. J. Cohen Test of dynamic closed-loop baroreflex and autoregulatory control of total peripheral resistance in intact and conscious sheep Am J Physiol Heart Circ Physiol, November 1, 2004; 287(5): H2274 - H2286. [Abstract] [Full Text] [PDF]