HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 287/5/H2341    most recent 00179.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Torres, L. N. Articles by Pittman, R. N. Search for Related Content PubMed PubMed Citation Articles by Torres, L. N. Articles by Pittman, R. N.

Continuous peripheral resistance measurement during hemorrhagic hypotension

Departments of ¹Physiology, ²Emergency Medicine, and ³Anesthesiology, Virginia Commonwealth University Reanimation Engineering Shock Center, Virginia Commonwealth University Health System, Richmond, Virginia 23298-0401

Submitted 24 February 2004 ; accepted in final form 18 June 2004

We tested the hypotheses that continuous total peripheral resistance (TPR) measurements are superior to intermittent data collection and that variables related to TPR can be used to distinguish between survivors and nonsurvivors (NS), respectively, of prolonged hemorrhagic hypotension (HH). One week after a transit-time ultrasound probe was implanted on their ascending aortas, 21 rats were subjected to 4 h of HH at 40 mmHg. Measurements were made before and up to 4 h after initiation of HH. Additional bleeding or Ringer L-lactate (RL) infusion was used to maintain HH. TPR was continuously measured online using recordings of blood flow and arterial pressure. Approximately 67% of the rats survived 3 h; others were considered NS. Data collected at 30-min intervals failed to detect the maximum value of TPR (TPR_max). The times to reach TPR_max were similar for survivors and NS and were strongly correlated with the bleeding end points and with the RL infusion-onset times. However, survivors showed higher TPR_max values than NS (P < 0.005) and had a significantly longer period than NS during which TPR was above baseline level (116 ± 20 vs. 51 ± 10 min). In conclusion, 1) the transit-time ultrasound technique at high sampling rate allowed continuous and accurate real-time monitoring of TPR, 2) the bleeding end point and RL infusion-onset times may be used as surrogates of the time to TPR_max, 3) TPR_max of survivors and NS could be detected only using a continuous TPR measurement, and 4) differences between survivors and NS could be revealed by the continuous TPR curve.

hemorrhage; blood pressure; total peripheral resistance; cardiac output; transit-time ultrasound

This article has been cited by other articles:

				J. L. Atkins, B. W. Day, M. T. Handrigan, Z. Zhang, M. B. Pamnani, and N. V. Gorbunov Brisk production of nitric oxide and associated formation of S-nitrosothiols in early hemorrhage J Appl Physiol, April 1, 2006; 100(4): 1267 - 1277. [Abstract] [Full Text] [PDF]