AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 288: H705-H709, 2005. First published October 7, 2004; doi:10.1152/ajpheart.01222.2003
0363-6135/05 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
288/2/H705    most recent
01222.2003v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Inan, M.
Right arrow Articles by Yologlu, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Inan, M.
Right arrow Articles by Yologlu, S.

Induced angiogenesis with intramedullary direct current: experimental research

Muharrem Inan,1 Ilker Alat,2 Iclal Gurses,3 Ersoy Kekilli,4 Ramazan Kutlu,5 Ahmet Eskin,1 Omer Murat Aydin,4 Haci Bostan,1 and Saim Yologlu6

Departments of 1Orthopedics and Traumatology, 2Cardiovascular Surgery, 3Pathology, 4Nuclear Medicine, 5Radiology, and 6Biostatistics, Inönü University and Turgut Özal Medical Center, Malatya, Turkey

Submitted 22 December 2003 ; accepted in final form 4 October 2004

The purpose of this study was to evaluate angiogenesis after the use of intramedullary direct electrical current in rabbit tibia. Thirty-two New Zealand rabbits were divided into four groups: group 1, false electrode group; group 2, hole group; group 3, control group; and group 4, intramedullary electrical stimulation group. One-half of the rabbits in each group were evaluated angiographically, pathologically, and scintigraphically on day 7, and the rest were evaluated on day 21. Results proved that electrical stimulation was not capable of the induction of angiogenesis in the subjects killed on day 7 and day 21. Furthermore, we found some fibrotic changes secondary to electrical stimulation on day 7 (P = 0.04) and day 21 (P = 0.01). However, an increase in new capillary vessels occurred in the false electrode group (P = 0.02). We found no useful effect of electrical stimulation in our study, a finding that is possibly due to our use of a method previously undocumented in the literature. We believe that this study can be the new baseline for further studies into the stimulation or inhibition of angiogenesis using intramedullary wire with or without electrical stimulation.

medullary canal; Alat's transparency; K-wire


Address for reprint requests and other correspondence: M. Inan, Inönü Üniversitesi Tip Fakültesi, Turgut Özal Tip Merkezi, Ortopedi ve Travmatoloji Anabilim Dali, 44069 Malatya, Turkey (E-mail: minan{at}inonu.edu.tr)






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2005 by the American Physiological Society.