HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 288/2/H737    most recent 00357.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (5) Citing Articles via Google Scholar Google Scholar Articles by Monahan, K. D. Articles by Ray, C. A. Search for Related Content PubMed PubMed Citation Articles by Monahan, K. D. Articles by Ray, C. A.

Cyclooxygenase inhibition and baroreflex sensitivity in humans

Departments of Medicine (Cardiology) and Cellular and Molecular Physiology, General Clinical Research Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania

Submitted 13 April 2004 ; accepted in final form 13 October 2004

Animal studies suggest that prostanoids (i.e., such as prostacyclin) may sensitize or impair baroreceptor and/or baroreflex responsiveness depending on the site of administration and/or inhibition. We tested the hypothesis that acute inhibition of cyclooxygenase (COX), the rate-limiting enzyme in prostanoid synthesis, impairs baroreflex regulation of cardiac period (R-R interval) and muscle sympathetic nerve activity (MSNA) in humans and augments pressor reactivity. Baroreflex sensitivity (BRS) was determined at baseline (preinfusion) and 60 min after (postinfusion) intravenous infusion of a COX antagonist (ketorolac; 45 mg) (24 ± 1 yr; n = 12) or saline (25 ± 1 yr; n = 12). BRS was assessed by using the modified Oxford technique (bolus intravenous infusion of nitroprusside followed by phenylephrine). BRS was quantified as the slope of the linear portion of the 1) R-R interval-systolic blood pressure relation (cardiovagal BRS) and 2) MSNA-diastolic blood pressure relation (sympathetic BRS) during pharmacological changes in arterial blood pressure. Ketorolac did not alter cardiovagal (19.4 ± 2.1 vs. 18.4 ± 2.4 ms/mmHg preinfusion and postinfusion, respectively) or sympathetic BRS (–2.9 ± 0.7 vs. –2.6 ± 0.4 arbitrary units·beat^–1·mmHg^–1) but significantly decreased a plasma biomarker of prostanoid generation (plasma thromboxane B₂) by 53 ± 11%. Cardiovagal BRS (21.3 ± 3.8 vs. 21.2 ± 3.0 ms/mmHg), sympathetic BRS (–3.4 ± 0.3 vs. –3.2 ± 0.2 arbitrary units·beat^–1·mmHg^–1), and thromboxane B₂ (change in –1 ± 12%) were unchanged in the control (saline infusion) group. Pressor responses to steady-state incremental (0.5, 1.0, and 1.5 µg·kg^–1·min^–1) infusion (5 min/dose) of phenylephrine were not altered by ketorolac (n = 8). Collectively, these data indicate that acute pharmacological antagonism of the COX enzyme does not impair BRS (cardiovagal or sympathetic) or augment pressor reactivity in healthy young adults.

autonomic nervous system; blood pressure; baroreceptor; prostaglandin

This article has been cited by other articles:

				R. Kanbar, B. Chapuis, V. Orea, C. Barres, and C. Julien Baroreflex control of lumbar and renal sympathetic nerve activity in conscious rats Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2008; 295(1): R8 - R14. [Abstract] [Full Text] [PDF]

				J. Cui, R. Moradkhan, V. Mascarenhas, A. Momen, and L. I. Sinoway Cyclooxygenase inhibition attenuates sympathetic responses to muscle stretch in humans Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2693 - H2700. [Abstract] [Full Text] [PDF]

				A. Momen, J. Cui, P. McQuillan, and L. I. Sinoway Local prostaglandin blockade attenuates muscle mechanoreflex-mediated renal vasoconstriction during muscle stretch in humans Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2184 - H2190. [Abstract] [Full Text] [PDF]

				J. Cui, P. McQuillan, A. Momen, C. Blaha, R. Moradkhan, V. Mascarenhas, C. Hogeman, A. Krishnan, and L. I. Sinoway The role of the cyclooxygenase products in evoking sympathetic activation in exercise Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1861 - H1868. [Abstract] [Full Text] [PDF]

				K. D. Monahan, D. J. Dyckman, and C. A. Ray Effect of acute hyperlipidemia on autonomic and cardiovascular control in humans J Appl Physiol, July 1, 2007; 103(1): 162 - 169. [Abstract] [Full Text] [PDF]

				K. D. Monahan, U. A. Leuenberger, and C. A. Ray Aldosterone impairs baroreflex sensitivity in healthy adults Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H190 - H197. [Abstract] [Full Text] [PDF]

				K. D. Monahan, U. A. Leuenberger, and C. A. Ray Effect of repetitive hypoxic apnoeas on baroreflex function in humans J. Physiol., July 15, 2006; 574(2): 605 - 613. [Abstract] [Full Text] [PDF]

				M. C. O. Salgado, S. V. S. Justo, L. F. Joaquim, R. Fazan Jr., and H. C. Salgado Role of nitric oxide and prostanoids in attenuation of rapid baroreceptor resetting Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1059 - H1063. [Abstract] [Full Text] [PDF]