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Am J Physiol Heart Circ Physiol 288: H1203-H1208, 2005. First published October 21, 2004; doi:10.1152/ajpheart.00681.2004
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Role of impaired myocardial relaxation in the production of elevated left ventricular filling pressure

Ilan Hay, Jonathan Rich, Paul Ferber, Daniel Burkhoff, and Mathew S. Maurer

College of Physicians and Surgeons, Columbia University, New York City, New York

Submitted 9 July 2004 ; accepted in final form 14 October 2004

Although present in many patients with heart failure and a normal ejection fraction, the role of isolated impairments in active myocardial relaxation in the genesis of elevated filling pressures is not well characterized. Because of difficulties in determining the effect of prolonged myocardial relaxation in vivo, we used a cardiovascular simulated computer model. The effect of myocardial relaxation, as assessed by {tau} (exponential time constant of relaxation), on pulmonary vein pressure (PVP) and left ventricular end-diastolic pressure (LVEDP) was investigated over a wide range of {tau} values (20–100 ms) and heart rate (60–140 beats/min) while keeping end-diastolic volume constant. Cardiac output was recorded over a wide range of {tau} and heart rate while keeping PVP constant. The effect of systolic intervals was investigated by changing time to end systole at the same heart rate. At a heart rate of 60 beats/min, increases in {tau} from a baseline to extreme value of 100 ms cause only a minor increase in PVP of 3 mmHg. In contrast, at 120 beats/min, the same increase in {tau} increases PVP by 23 mmHg. An increase in filling pressures at high heart rates was attributable to incomplete relaxation. The PVP-LVEDP gradient was not constant and increased with increasing {tau} and heart rate. Prolonged systolic intervals augmented the effects of {tau} on PVP. Impaired myocardial relaxation is an important determinant of PVP and cardiac output only during rapid heart rate and especially when combined with prolonged systolic intervals. These findings clarify the role of myocardial relaxation in the pathogenesis of elevated filling pressures characteristic of heart failure.

heart failure; diastolic dysfunction; heart failure with normal ejection fraction; computer simulation


Address for reprint requests and other correspondence: M. Maurer, Columbia Univ., College of Physicians & Surgeons, Division of Cardiology, 177 Fort Washington Ave., MHB 5–435, New York City, NY 10032 (E-mail: msm10{at}columbia.edu)




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