| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1Division of Cardiovascular Disease, Department of Medicine; 2The Comprehensive Cancer Center; 3Department of Physiology and Biophysics and The Clinical Nutrition Research Center, University of Alabama, Birmingham, Alabama; and 4Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
Submitted 7 September 2004 ; accepted in final form 14 December 2004
The goal of this study was to determine whether changes in cardiac metabolism in Type 2 diabetes are associated with contractile dysfunction or impaired response to ischemia. Hearts from Zucker diabetic fatty (ZDF) and lean control rats were isolated and perfused with glucose, lactate, pyruvate, and palmitate. The rates of glucose, lactate, pyruvate, and palmitate oxidation rates and glycolysis were determined during baseline perfusion and low-flow ischemia (LFI; 0.3 ml/min for 30 min) and after LFI and reperfusion. Under all conditions, ATP synthesis from palmitate was increased and synthesis from lactate was decreased in the ZDF group, whereas the contribution from glucose was unchanged. During baseline perfusion, the rate of glycolysis was lower in the ZDF group; however, during LFI and reperfusion, there were no differences between groups. Despite these metabolic shifts, there were no differences in oxygen consumption or ATP production rates between the groups under any perfusion conditions. Cardiac function was slightly depressed before LFI in the ZDF group, but during reperfusion, function was improved relative to the control group despite the increased dependence on fatty acids for energy production. These data suggest that in this model of diabetes, the shift from carbohydrates to fatty acids for oxidative energy production did not increase myocardial oxygen consumption and was not associated with impaired response to ischemia and reperfusion.
contractile dysfunction; ischemia; nuclear magnetic resonance spectroscopy; carbohydrate metabolism
This article has been cited by other articles:
|
|
 |
|
  A. Bonen, G. P. Holloway, N. N. Tandon, X.-X. Han, J. McFarlan, J. F. C. Glatz, and J. J. F. P. Luiken Cardiac and skeletal muscle fatty acid transport and transporters and triacylglycerol and fatty acid oxidation in lean and Zucker diabetic fatty rats Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2009; 297(4): R1202 - R1212. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Bugger and E. D. Abel Rodent models of diabetic cardiomyopathy Dis. Model. Mech., September 1, 2009; 2(9-10): 454 - 466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Radovits, S. Korkmaz, S. Loganathan, E. Barnucz, T. Bomicke, R. Arif, M. Karck, and G. Szabo Comparative investigation of the left ventricular pressure-volume relationship in rat models of type 1 and type 2 diabetes mellitus Am J Physiol Heart Circ Physiol, July 1, 2009; 297(1): H125 - H133. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-G. Niu and R. D. Evans Myocardial metabolism of triacylglycerol-rich lipoproteins in type 2 diabetes J. Physiol., July 1, 2009; 587(13): 3301 - 3315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. D. Abel, S. E. Litwin, and G. Sweeney Cardiac Remodeling in Obesity Physiol Rev, April 1, 2008; 88(2): 389 - 419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Evans and Y. Niu Hypolipidaemic effects of high-dose insulin therapy Br. J. Anaesth., April 1, 2008; 100(4): 429 - 433. [Full Text] [PDF]
|
|
|
|
 |
|
 P. Herrero, C. S. Dence, A. R. Coggan, Z. Kisrieva-Ware, P. Eisenbeis, and R. J. Gropler L-3-11C-Lactate as a PET Tracer of Myocardial Lactate Metabolism: A Feasibility Study J. Nucl. Med., December 1, 2007; 48(12): 2046 - 2055. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Noland, T. L. Woodlief, B. R. Whitfield, S. M. Manning, J. R. Evans, R. W. Dudek, R. M. Lust, and R. N. Cortright Peroxisomal-mitochondrial oxidation in a rodent model of obesity-associated insulin resistance Am J Physiol Endocrinol Metab, October 1, 2007; 293(4): E986 - E1001. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. D. Lopaschuk, C. D.L. Folmes, and W. C. Stanley Cardiac Energy Metabolism in Obesity Circ. Res., August 17, 2007; 101(4): 335 - 347. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Marsh, P. C. Powell, A. Agarwal, L. J. Dell'Italia, and J. C. Chatham Cardiovascular dysfunction in Zucker obese and Zucker diabetic fatty rats: role of hydronephrosis Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H292 - H298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Boudina and E. D. Abel Diabetic Cardiomyopathy Revisited Circulation, June 26, 2007; 115(25): 3213 - 3223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Fulop, M. M. Mason, K. Dutta, P. Wang, A. J. Davidoff, R. B. Marchase, and J. C. Chatham Impact of Type 2 diabetes and aging on cardiomyocyte function and O-linked N-acetylglucosamine levels in the heart Am J Physiol Cell Physiol, April 1, 2007; 292(4): C1370 - C1378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. An and B. Rodrigues Role of changes in cardiac metabolism in development of diabetic cardiomyopathy Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1489 - H1506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Chabowski, J. C. Chatham, N. N. Tandon, J. Calles-Escandon, J. F. C. Glatz, J. J. F. P. Luiken, and A. Bonen Fatty acid transport and FAT/CD36 are increased in red but not in white skeletal muscle of ZDF rats Am J Physiol Endocrinol Metab, September 1, 2006; 291(3): E675 - E682. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Boudina and E. D. Abel Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes. Physiology, August 1, 2006; 21: 250 - 258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. G. Poornima, P. Parikh, and R. P. Shannon Diabetic Cardiomyopathy: The Search for a Unifying Hypothesis Circ. Res., March 17, 2006; 98(5): 596 - 605. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O.-J. How, E. Aasum, D. L. Severson, W.Y. A. Chan, M. F. Essop, and T. S. Larsen Increased Myocardial Oxygen Consumption Reduces Cardiac Efficiency in Diabetic Mice Diabetes, February 1, 2006; 55(2): 466 - 473. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
