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Estimating oxygen consumption rates of arteriolar walls under physiological conditions in rat skeletal muscle

Department of Biomedical Engineering, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

Submitted 17 August 2004 ; accepted in final form 19 January 2005

To examine the effects of vascular tone reduction on O₂ consumption of the vascular wall, we determined the O₂ consumption rates of arteriolar walls under normal conditions and during vasodilation induced by topical application of papaverine. A phosphorescence quenching technique was used to quantify intra- and perivascular PO₂ in rat cremaster arterioles with different branching orders. Then, the measured radial PO₂ gradients and a theoretical model were used to estimate the O₂ consumption rates of the arteriolar walls. The vascular O₂ consumption rates of functional arterioles were >100 times greater than those observed in in vitro experiments. The vascular O₂ consumption rate was highest in first-order (1A) arterioles, which are located upstream, and sequentially decreased downstream in 2A and 3A arterioles under normal conditions. During papaverine-induced vasodilation, on the other hand, the O₂ consumption rates of the vascular walls decreased to similar levels, suggesting that the high O₂ consumption rates of 1A arterioles under normal conditions depend in part on the workload of the vascular smooth muscle. These results strongly support the hypothesis that arteriolar walls consume a significant amount of O₂ compared with the surrounding tissue. Furthermore, the reduction of vascular tone of arteriolar walls may facilitate an efficient supply of O₂ to the surrounding tissue.

oxygen diffusion; vascular wall; vascular tone; vasodilation; papaverine

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