HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 289/1/H295    most recent 00830.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (23) Citing Articles via Google Scholar Google Scholar Articles by Shibata, M. Articles by Kamiya, A. Search for Related Content PubMed PubMed Citation Articles by Shibata, M. Articles by Kamiya, A.

Estimating oxygen consumption rates of arteriolar walls under physiological conditions in rat skeletal muscle

Department of Biomedical Engineering, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

Submitted 17 August 2004 ; accepted in final form 19 January 2005

To examine the effects of vascular tone reduction on O₂ consumption of the vascular wall, we determined the O₂ consumption rates of arteriolar walls under normal conditions and during vasodilation induced by topical application of papaverine. A phosphorescence quenching technique was used to quantify intra- and perivascular PO₂ in rat cremaster arterioles with different branching orders. Then, the measured radial PO₂ gradients and a theoretical model were used to estimate the O₂ consumption rates of the arteriolar walls. The vascular O₂ consumption rates of functional arterioles were >100 times greater than those observed in in vitro experiments. The vascular O₂ consumption rate was highest in first-order (1A) arterioles, which are located upstream, and sequentially decreased downstream in 2A and 3A arterioles under normal conditions. During papaverine-induced vasodilation, on the other hand, the O₂ consumption rates of the vascular walls decreased to similar levels, suggesting that the high O₂ consumption rates of 1A arterioles under normal conditions depend in part on the workload of the vascular smooth muscle. These results strongly support the hypothesis that arteriolar walls consume a significant amount of O₂ compared with the surrounding tissue. Furthermore, the reduction of vascular tone of arteriolar walls may facilitate an efficient supply of O₂ to the surrounding tissue.

oxygen diffusion; vascular wall; vascular tone; vasodilation; papaverine

This article has been cited by other articles:

				R. G. Evans, B. S. Gardiner, D. W. Smith, and P. M. O'Connor Intrarenal oxygenation: unique challenges and the biophysical basis of homeostasis Am J Physiol Renal Physiol, November 1, 2008; 295(5): F1259 - F1270. [Abstract] [Full Text] [PDF]

				K. R. Olson Hydrogen sulfide and oxygen sensing: implications in cardiorespiratory control J. Exp. Biol., September 1, 2008; 211(17): 2727 - 2734. [Abstract] [Full Text] [PDF]

				A. S. Golub and R. N. Pittman PO2 measurements in the microcirculation using phosphorescence quenching microscopy at high magnification Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2905 - H2916. [Abstract] [Full Text] [PDF]

				P. Cabrales, A. G. Tsai, and M. Intaglietta Modulation of Perfusion and Oxygenation by Red Blood Cell Oxygen Affinity during Acute Anemia Am. J. Respir. Cell Mol. Biol., March 1, 2008; 38(3): 354 - 361. [Abstract] [Full Text] [PDF]

				C.-L. Leong, W. P. Anderson, P. M. O'Connor, and R. G. Evans Evidence that renal arterial-venous oxygen shunting contributes to dynamic regulation of renal oxygenation Am J Physiol Renal Physiol, June 1, 2007; 292(6): F1726 - F1733. [Abstract] [Full Text] [PDF]

				J. R. Koenitzer, T. S. Isbell, H. D. Patel, G. A. Benavides, D. A. Dickinson, R. P. Patel, V. M. Darley-Usmar, J. R. Lancaster Jr, J. E. Doeller, and D. W. Kraus Hydrogen sulfide mediates vasoactivity in an O2-dependent manner Am J Physiol Heart Circ Physiol, April 1, 2007; 292(4): H1953 - H1960. [Abstract] [Full Text] [PDF]

				W. Zhang and A. Edwards A model of nitric oxide tubulovascular cross talk in a renal outer medullary cross section Am J Physiol Renal Physiol, February 1, 2007; 292(2): F711 - F722. [Abstract] [Full Text] [PDF]

				M. Kawata, M. Sekino, S. Takamoto, S. Ueno, S. Yamaguchi, K. Kitahori, H. Tsukihara, Y. Suematsu, M. Ono, N. Motomura, et al. Retrograde cerebral perfusion with intermittent pressure augmentation provides adequate neuroprotection: Diffusion- and perfusion-weighted magnetic resonance imaging study in an experimental canine model J. Thorac. Cardiovasc. Surg., October 1, 2006; 132(4): 933 - 940. [Abstract] [Full Text] [PDF]

				M. Shibata, K. Qin, S. Ichioka, and A. Kamiya Vascular wall energetics in arterioles during nitric oxide-dependent and -independent vasodilation J Appl Physiol, June 1, 2006; 100(6): 1793 - 1798. [Abstract] [Full Text] [PDF]

				P. Cabrales, A. G. Tsai, P. C. Johnson, and M. Intaglietta Oxygen release from arterioles with normal flow and no-flow conditions J Appl Physiol, May 1, 2006; 100(5): 1569 - 1576. [Abstract] [Full Text] [PDF]

				P. Cabrales, A. G. Tsai, and M. Intaglietta Nitric oxide regulation of microvascular oxygen exchange during hypoxia and hyperoxia J Appl Physiol, April 1, 2006; 100(4): 1181 - 1187. [Abstract] [Full Text] [PDF]

				M. Shibata, S. Ichioka, and A. Kamiya Nitric oxide modulates oxygen consumption by arteriolar walls in rat skeletal muscle Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2673 - H2679. [Abstract] [Full Text] [PDF]