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Am J Physiol Heart Circ Physiol 289: H57-H65, 2005. First published February 25, 2005; doi:10.1152/ajpheart.01001.2004
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Variants of the tissue-sensor array window chamber

Milan T. Makale, Peter C. Chen, and David A. Gough

Department of Bioengineering, University of California-San Diego, La Jolla, California

Submitted 1 October 2004 ; accepted in final form 22 February 2005

Sensors are being developed that can be implanted in tissues for continuous monitoring of oxygen, glucose, and other metabolites. However, there have been difficulties in inferring metabolite concentrations in blood from the signals of tissue sensors due to the properties of tissues at the implant site and local physiological phenomena that can affect sensor responses. A multisensor array has been previously developed for implantation in a hamster skinfold window chamber preparation to study these effects. The preparation allows recording of concentration-dependent signals from multiple sensors while nondestructively visualizing the adjacent tissue and microvascular function. Variants of the tissue-sensor array window chamber described here have respective advantages over the original chamber design, including improved tissue visualization and reduced surgical intervention, and allow exposure of the sensor to different tissues. Results indicate that mass transfer within tissues is heterogeneous, and sensor signals are affected by variable perfusion of local microvasculature in addition to vascular metabolite concentration. These observations suggest new strategies for sensor design and operation. Window chamber variants are important tools for validation of implanted sensors.

implanted biosensors; tissue visualization; sensor validation


Address for reprint requests and other correspondence: D. A. Gough, Dept. of Bioengineering, Univ. of California-San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0412 (E-mail: dgough{at}ucsd.edu)






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