HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (24) Citing Articles via Google Scholar Google Scholar Articles by Berenji, K. Articles by Hill, J. A. Search for Related Content PubMed PubMed Citation Articles by Berenji, K. Articles by Hill, J. A.

INVITED REVIEW

Does load-induced ventricular hypertrophy progress to systolic heart failure?

³Donald W. Reynolds Cardiovascular Clinical Research Center and the Departments of ¹Internal Medicine and ²Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas

Ventricular hypertrophy develops in response to numerous forms of cardiac stress, including pressure or volume overload, loss of contractile mass from prior infarction, neuroendocrine activation, and mutations in genes encoding sarcomeric proteins. Hypertrophic growth is believed to have a compensatory role that diminishes wall stress and oxygen consumption, but Framingham and other studies established ventricular hypertrophy as a marker for increased risk of developing chronic heart failure, suggesting that hypertrophy may have maladaptive features. However, the relative contribution of comorbid disease to hypertrophy-associated systolic failure is unknown. For instance, coronary artery disease is induced by many of the same risk factors that cause hypertrophy and can itself lead to systolic dysfunction. It is uncertain, therefore, whether ventricular hypertrophy commonly progresses to systolic dysfunction without the contribution of intervening ischemia or infarction. In this review, we summarize findings from epidemiologic studies, preclinical experiments in animals, and clinical trials to lay out what is known—and not known—about this important question.

congestive heart failure; eccentric hypertrophy; concentric hypertrophy; systolic dysfunction

This article has been cited by other articles:

				J. A. Hill and E. N. Olson Cardiac Plasticity N. Engl. J. Med., March 27, 2008; 358(13): 1370 - 1380. [Full Text] [PDF]

				C. F.M.Z. Clemente, T. F. Tornatore, T. H. Theizen, A. C. Deckmann, T. C. Pereira, I. Lopes-Cendes, J. R. M. Souza, and K. G. Franchini Targeting Focal Adhesion Kinase With Small Interfering RNA Prevents and Reverses Load-Induced Cardiac Hypertrophy in Mice Circ. Res., December 7, 2007; 101(12): 1339 - 1348. [Abstract] [Full Text] [PDF]

				E. S. Buys, M. J. Raher, S. L. Blake, T. G. Neilan, A. R. Graveline, J. J. Passeri, M. Llano, T. M. Perez-Sanz, F. Ichinose, S. Janssens, et al. Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H620 - H627. [Abstract] [Full Text] [PDF]

				J. K. Cleal, K. R. Poore, J. P. Boullin, O. Khan, R. Chau, O. Hambidge, C. Torrens, J. P. Newman, L. Poston, D. E. Noakes, et al. Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood PNAS, May 29, 2007; 104(22): 9529 - 9533. [Abstract] [Full Text] [PDF]

				L. S. Spruill and P. J. McDermott Regulation of c-jun mRNA expression in adult cardiocytes by MAP kinase interacting kinase-1 (MNK1) FASEB J, October 1, 2006; 20(12): 2133 - 2135. [Abstract] [Full Text] [PDF]

				B. M. R. Carvalho, R. A. Bassani, K. G. Franchini, and J. W. M. Bassani Enhanced calcium mobilization in rat ventricular myocytes during the onset of pressure overload-induced hypertrophy Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1803 - H1813. [Abstract] [Full Text] [PDF]

				Y. G. Ni, K. Berenji, N. Wang, M. Oh, N. Sachan, A. Dey, J. Cheng, G. Lu, D. J. Morris, D. H. Castrillon, et al. Foxo Transcription Factors Blunt Cardiac Hypertrophy by Inhibiting Calcineurin Signaling Circulation, September 12, 2006; 114(11): 1159 - 1168. [Abstract] [Full Text] [PDF]

				B. A. Rothermel and J. A. Hill Molecular Mechanisms of Cardiac Hypertrophy and Failure Circulation, June 13, 2006; 113(23): e853 - e853. [Full Text] [PDF]

				Y. J. Kang Cardiac Hypertrophy: A Risk Factor for QT-Prolongation and Cardiac Sudden Death Toxicol Pathol, January 1, 2006; 34(1): 58 - 66. [Abstract] [PDF]

				B. A. Rothermel, K. Berenji, P. Tannous, W. Kutschke, A. Dey, B. Nolan, K.-D. Yoo, E. Demetroulis, M. Gimbel, B. Cabuay, et al. Differential activation of stress-response signaling in load-induced cardiac hypertrophy and failure Physiol Genomics, September 21, 2005; 23(1): 18 - 27. [Abstract] [Full Text] [PDF]