| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
INVITED REVIEW
1Division of Cardiology, Department of Medicine, Columbia University, New York, New York; 2Divisions of Mathematical Biology and Cardiology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts; and 3Research Institute, National Cardiovascular Center, Suita, Osaka, Japan
Assessment of left ventricular systolic and diastolic pump properties is fundamental to advancing the understanding of cardiovascular pathophysiology and therapeutics, especially for heart failure. The use of end-systolic and end-diastolic pressure-volume relationships derived from measurements of instantaneous left ventricular pressure-volume loops emerged in the 1970s as a comprehensive approach for this purpose. As invasive and noninvasive techniques for measuring ventricular volume improved over the past decades, these relations have become commonly used by basic, translational, and clinical researchers. This review summarizes 1) the basic concepts underlying pressure-volume analysis of ventricular and myocardial systolic and diastolic properties, 2) deviations from ideal conditions typically encountered in real-life applications, 3) how these relationships are appropriately analyzed, including statistical analyses, and 4) the most common problems encountered by investigators and the appropriate remedies. The goal is to provide practical information and simple guidelines for accurate application and interpretation of pressure-volume data as they pertain to characterization of ventricular and myocardial properties in health and disease.
systole; diastole; ventricular mechanics; end-systolic pressure-volume relationship; end-diastolic pressure-volume relationship
This article has been cited by other articles:
|
|
 |
|
  M. P. Turakhia, D. D. McManus, M. A. Whooley, and N. B. Schiller Increase in end-systolic volume after exercise independently predicts mortality in patients with coronary heart disease: data from the Heart and Soul Study Eur. Heart J., July 3, 2009; (2009) ehp270v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. T. Burns, A. La Gerche, D. L. Prior, and A. I. MacIsaac Left Ventricular Untwisting Is an Important Determinant of Early Diastolic Function J. Am. Coll. Cardiol. Img., June 1, 2009; 2(6): 709 - 716. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Donaldson, S. Eder, C. Baker, M. J. Aronovitz, A. D. Weiss, M. Hall-Porter, F. Wang, A. Ackerman, R. H. Karas, J. D. Molkentin, et al. Estrogen Attenuates Left Ventricular and Cardiomyocyte Hypertrophy by an Estrogen Receptor-Dependent Pathway That Increases Calcineurin Degradation Circ. Res., January 30, 2009; 104(2): 265 - 275. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. D. Chantler, E. G. Lakatta, and S. S. Najjar Arterial-ventricular coupling: mechanistic insights into cardiovascular performance at rest and during exercise J Appl Physiol, October 1, 2008; 105(4): 1342 - 1351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P Steendijk, E Meliga, M Valgimigli, F J Ten Cate, and P W Serruys Acute effects of alcohol septal ablation on systolic and diastolic left ventricular function in patients with hypertrophic obstructive cardiomyopathy Heart, October 1, 2008; 94(10): 1318 - 1322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. A. Jaber, C. Maniu, J. Krysiak, B. P. Shapiro, D. M. Meyer, W. A. Linke, and M. M. Redfield Titin Isoforms, Extracellular Matrix, and Global Chamber Remodeling in Experimental Dilated Cardiomyopathy: Functional Implications and Mechanistic Insight Circ Heart Fail, September 1, 2008; 1(3): 192 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Shioura, D. L. Geenen, and P. H. Goldspink Sex-related changes in cardiac function following myocardial infarction in mice Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2008; 295(2): R528 - R534. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Zhang and S. J. Kovacs The diastatic pressure-volume relationship is not the same as the end-diastolic pressure-volume relationship Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2750 - H2760. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Westermann, M. Kasner, P. Steendijk, F. Spillmann, A. Riad, K. Weitmann, W. Hoffmann, W. Poller, M. Pauschinger, H.-P. Schultheiss, et al. Role of Left Ventricular Stiffness in Heart Failure With Normal Ejection Fraction Circulation, April 22, 2008; 117(16): 2051 - 2060. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Westermann, J. Mersmann, A. Melchior, T. Freudenberger, C. Petrik, L. Schaefer, R. Lullmann-Rauch, O. Lettau, C. Jacoby, J. Schrader, et al. Biglycan Is Required for Adaptive Remodeling After Myocardial Infarction Circulation, March 11, 2008; 117(10): 1269 - 1276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Bal, W. B. de Vries, M. F. M. van Oosterhout, J. Baan, E. E. van der Wall, F. van Bel, and P. Steendijk Long-term cardiovascular effects of neonatal dexamethasone treatment: hemodynamic follow-up by left ventricular pressure-volume loops in rats J Appl Physiol, February 1, 2008; 104(2): 446 - 450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. P. Shapiro, T. E. Owan, S. Mohammed, M. Kruger, W. A. Linke, J. C. Burnett Jr, and M. M. Redfield Mineralocorticoid Signaling in Transition to Heart Failure With Normal Ejection Fraction Hypertension, February 1, 2008; 51(2): 289 - 295. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Fannelop, G. O. Dahle, K. Matre, C. A. Moen, A. Mongstad, F. Eliassen, L. Segadal, and K. Grong Esmolol before 80 min of cardiac arrest with oxygenated cold blood cardioplegia alleviates systolic dysfunction. An experimental study in pigs Eur. J. Cardiothorac. Surg., January 1, 2008; 33(1): 9 - 17. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Jaber, C. S. P. Lam, D. M. Meyer, and M. M. Redfield Revisiting methods for assessing and comparing left ventricular diastolic stiffness: impact of relaxation, external forces, hypertrophy, and comparators Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2738 - H2746. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Shioura, D. L. Geenen, and P. H. Goldspink Assessment of cardiac function with the pressure-volume conductance system following myocardial infarction in mice Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2870 - H2877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Ferrazzi, M. Senni, M. R. Iascone, M. Merlo, M. Triggiani, R. Lorusso, P. Herijgers, J. J. Schreuder, S. Pentiricci, A. Iacovoni, et al. Implantation of an Elastic Ring at Equator of the Left Ventricle Influences Cardiac Mechanics in Experimental Acute Ventricular Dysfunction J. Am. Coll. Cardiol., October 30, 2007; 50(18): 1791 - 1798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. P. Shapiro, C. S.P. Lam, J. B. Patel, S. F. Mohammed, M. Kruger, D. M. Meyer, W. A. Linke, and M. M. Redfield Acute and Chronic Ventricular-Arterial Coupling in Systole and Diastole: Insights From an Elderly Hypertensive Model Hypertension, September 1, 2007; 50(3): 503 - 511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. F. Renna, S. M. MacDonnell, P. O. Reger, D. L. Crabbe, S. R. Houser, and J. R. Libonati Relative systolic dysfunction in female spontaneously hypertensive rat myocardium J Appl Physiol, July 1, 2007; 103(1): 353 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Clark, R. A. Flavell, M. E. Faircloth, R. J. Davis, R. J. Heads, and M. S. Marber Post-infarction remodeling is independent of mitogen-activated protein kinase kinase 3 (MKK3) Cardiovasc Res, June 1, 2007; 74(3): 466 - 470. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Sala-Mercado, R. L. Hammond, J.-K. Kim, P. J. McDonald, L. W. Stephenson, and D. S. O'Leary Heart failure attenuates muscle metaboreflex control of ventricular contractility during dynamic exercise Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2159 - H2166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S.P. Lam, V. L. Roger, R. J. Rodeheffer, F. Bursi, B. A. Borlaug, S. R. Ommen, D. A. Kass, and M. M. Redfield Cardiac Structure and Ventricular-Vascular Function in Persons With Heart Failure and Preserved Ejection Fraction From Olmsted County, Minnesota Circulation, April 17, 2007; 115(15): 1982 - 1990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Oceandy, E. J. Cartwright, M. Emerson, S. Prehar, F. M. Baudoin, M. Zi, N. Alatwi, L. Venetucci, K. Schuh, J. C. Williams, et al. Neuronal Nitric Oxide Synthase Signaling in the Heart Is Regulated by the Sarcolemmal Calcium Pump 4b Circulation, January 30, 2007; 115(4): 483 - 492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Gill, B. D. Jones, A. K. Corbly, J. Wang, J. C. Braz, G. E. Sandusky, J. Wang, and W. Shen Cardiac diastolic dysfunction in conscious dogs with heart failure induced by chronic coronary microembolization Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H3154 - H3158. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Burkhoff and A. S. Wechsler Surgical ventricular remodeling: A balancing act on systolic and diastolic properties. J. Thorac. Cardiovasc. Surg., September 1, 2006; 132(3): 459 - 463. [Full Text] [PDF]
|
|
|
|
|
|
S. A.F. Tulner, P. Steendijk, R. J.M. Klautz, J. J. Bax, M. J. Schalij, E. E. van der Wall, and R. A.E. Dion Surgical ventricular restoration in patients with ischemic dilated cardiomyopathy: Evaluation of systolic and diastolic ventricular function, wall stress, dyssynchrony, and mechanical efficiency by pressure-volume loops. J. Thorac. Cardiovasc. Surg., September 1, 2006; 132(3): 610 - 620. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Klotz, I. Hay, G. Zhang, M. Maurer, J. Wang, and D. Burkhoff Development of Heart Failure in Chronic Hypertensive Dahl Rats: Focus on Heart Failure With Preserved Ejection Fraction Hypertension, May 1, 2006; 47(5): 901 - 911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Claessens, D. Georgakopoulos, M. Afanasyeva, S. J. Vermeersch, H. D. Millar, N. Stergiopulos, N. Westerhof, P. R. Verdonck, and P. Segers Nonlinear isochrones in murine left ventricular pressure-volume loops: how well does the time-varying elastance concept hold? Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1474 - H1483. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
