HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Supplemental Figure All Versions of this Article: 289/3/H1153    most recent 00048.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (6) Citing Articles via Google Scholar Google Scholar Articles by García-Rivello, H. Articles by Hertig, C. M. Search for Related Content PubMed PubMed Citation Articles by García-Rivello, H. Articles by Hertig, C. M.

Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle

¹Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Buenos Aires; ²Centro de Investigaciones Cardiovasculares, Universidad de La Plata, La Plata; and ³División de Patología, Universidad Favaloro, Buenos Aires, Argentina; ⁴Medical School, University of California San Diego, and ⁵The Scripps Research Institute, La Jolla; and ⁶Center for Comparative Medicine, University of California Davis, Davis, California

Submitted 18 January 2005 ; accepted in final form 24 April 2005

The neuregulin receptor tyrosine kinase Erb-b4, initially linked to early cardiac development, is shown here to play a critical role in adult cardiac function. In wild-type mice, Erb-b4 protein localized to Z lines and to intercalated disks, suggesting a role in subcellular and intercellular communications of cardiomyocytes. Conditional inactivation of erb-b4 in ventricular muscle cells led to a severe dilated cardiomyopathy, characterized by thinned ventricular walls with eccentric hypertrophy, reduced contractility, and delayed conduction. This cardiac dysfunction may account for premature death in adult erb-b4-knockout mice. This study establishes a critical role for Erb-b4 in the maintenance of normal postnatal cardiac structure and function.

erb-b2; neuregulin; conditional knockout; mouse; heart

This article has been cited by other articles:

				K. Lemmens, K. Doggen, and G. W. De Keulenaer Role of Neuregulin-1/ErbB Signaling in Cardiovascular Physiology and Disease: Implications for Therapy of Heart Failure Circulation, August 21, 2007; 116(8): 954 - 960. [Abstract] [Full Text] [PDF]

				M. Hoshijima, R. Knoll, M. Pashmforoush, and K. R. Chien Reversal of Calcium Cycling Defects in Advanced Heart Failure: Toward Molecular Therapy J. Am. Coll. Cardiol., October 27, 2006; 48(9_Suppl_A): A15 - A23. [Abstract] [Full Text] [PDF]