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This Article Full Text Full Text (PDF) All Versions of this Article: 289/4/H1436    most recent 00368.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (12) Citing Articles via Google Scholar Google Scholar Articles by Shibamoto, T. Articles by Kurata, Y. Search for Related Content PubMed PubMed Citation Articles by Shibamoto, T. Articles by Kurata, Y.

Hepatic venoconstriction is involved in anaphylactic hypotension in rats

Department of Physiology, Kanazawa Medical University, Uchinada Ishikawa 920-0293, Japan

Submitted 14 April 2005 ; accepted in final form 20 May 2005

We determined the roles of liver and splanchnic vascular bed in anaphylactic hypotension in anesthetized rats and the effects of anaphylaxis on hepatic vascular resistances and liver weight in isolated perfused rat livers. In anesthetized rats sensitized with ovalbumin (1 mg), an intravenous injection of 0.6 mg ovalbumin caused not only a decrease in systemic arterial pressure from 120 ± 9 to 43 ± 10 mmHg but also an increase in portal venous pressure that persisted for 20 min after the antigen injection (the portal hypertension phase). The elimination of the splanchnic vascular beds, by the occlusions of the celiac and mesenteric arteries, combined with total hepatectomy attenuated anaphylactic hypotension during the portal hypertension phase. For the isolated perfused rat liver experiment, the livers derived from sensitized rats were hemoperfused via the portal vein at a constant flow. Using the double-occlusion technique to estimate the hepatic sinusoidal pressure, presinusoidal (R_pre) and postsinusoidal (R_post) resistances were calculated. An injection of antigen (0.015 mg) caused venoconstriction characterized by an almost selective increase in R_pre rather than R_post and liver weight loss. Taken together, these results suggest that liver and splanchnic vascular beds are involved in anaphylactic hypotension presumably because of anaphylactic presinusoidal contraction-induced portal hypertension, which induced splanchnic congestion resulting in a decrease in circulating blood volume and thus systemic arterial hypotension.

isolated perfused rat liver; anaphylaxis; hepatic circulation; portal hypertension; splanchnic congestion

This article has been cited by other articles:

				T. Shibamoto, T. Shimo, S. Cui, W. Zhang, H. Takano, Y. Kurata, and H. Tsuchida The roles of mast cells and Kupffer cells in rat systemic anaphylaxis Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2007; 293(6): R2202 - R2209. [Abstract] [Full Text] [PDF]

				W. Liu, H. Takano, T. Shibamoto, S. Cui, Z.-S. Zhao, W. Zhang, and Y. Kurata Involvement of splanchnic vascular bed in anaphylactic hypotension in anesthetized BALB/c mice Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2007; 293(5): R1947 - R1953. [Abstract] [Full Text] [PDF]