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This Article Full Text Full Text (PDF) All Versions of this Article: 289/4/H1577    most recent 00258.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wang, J.-F. Articles by Morgan, J. P. Search for Related Content PubMed PubMed Citation Articles by Wang, J.-F. Articles by Morgan, J. P.

Propranolol ameliorates and epinephrine exacerbates progression of acute and chronic viral myocarditis

¹Cardiovascular Division, Department of Medicine, and Harvard Thorndike Research Institute, and ³Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; and ²Cardiovascular Division, Department of Internal Medicine and Cardiology, Stadtkrankenhaus Soest, Soest, Germany

Submitted 16 March 2005 ; accepted in final form 20 May 2005

Recent studies point to important interactions between proinflammatory cytokines and neurohumoral mediators in heart failure. Here we investigate the influence of the -adrenergic system on cytokines and neurohumoral factors and the sequelae of viral myocarditis. In an experimental model with virus-infected BALB/c mice, we studied the acute and chronic effects of epinephrine and propranolol on myocardial morphology, cytokine gene expression, and survival. BALB/c mice were inoculated with the encephalomyocarditis virus (EMCV) or sham inoculated with saline and followed for 30 days. Epinephrine increased the severity of inflammatory cell infiltration and myocardial necrosis induced by EMCV. Gene expression of TNF-, IL-6, and IL-10 was markedly enhanced by epinephrine in EMCV-inoculated mice. Survival rate after 30 days was reduced to 40% in epinephrine-treated EMCV-inoculated mice compared with 70% in untreated EMCV-inoculated mice (P < 0.05). Treatment with the -blocker propranolol significantly decreased mortality, myocardial necrosis, and infiltration of inflammatory cells in EMCV-inoculated mice. Propranolol also suppressed gene expression of TNF-, IL-6, and IL-10. A single dose of epinephrine 120 days after EMCV inoculation caused sudden death in 70% of infected mice; propranolol significantly reduced incidence of death to 33%. These results indicate that acute and chronic stages of viral myocarditis are modulated by the -adrenergic system and its interactions with proinflammatory cytokines.

heart failure; arrhythmia; -adrenergic receptor stimulation; -blocker; proinflammatory cytokines; encephalomyocarditis virus

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