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This Article Full Text Full Text (PDF) All Versions of this Article: 289/6/H2450    most recent 00524.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (14) Citing Articles via Google Scholar Google Scholar Articles by Boissiere, J. Articles by Eder, V. Search for Related Content PubMed PubMed Citation Articles by Boissiere, J. Articles by Eder, V.

Doppler tissue imaging in assessment of pulmonary hypertension-induced right ventricle dysfunction

¹Laboratoire de Physiologie de la Paroi Artérielle EA3852, Faculté de Médecine, IFR 135 Imagerie Fonctionnelle, Université François Rabelais, Tours; and ²Pfizer Global Research and Development, Amboise, France

Submitted 19 May 2005 ; accepted in final form 17 July 2005

We aimed to assess the accuracy of Doppler tissue imaging (DTI) in detecting right ventricle (RV) dysfunction and electromechanical coupling alteration following pulmonary hypertension (PHT) in rat. PHT was induced by chronic hypoxia exposure (hypoxic PHT) or monocrotaline treatment (monocrotaline PHT). In both PHT models, we observed transparietal RV pressure increase and remodeling, including hypertrophy and dilation. Conventional echocardiography provided evidence for pulmonary outflow impairment with midsystolic notch and acceleration time decrease in PHT groups (21.7 ± 1.6 and 13.2 ± 2.9 ms in hypoxic and monocrotaline PHT groups vs. 28.1 ± 1.0 ms in control). RV shortening fraction was decreased in the monocrotaline PHT group compared with the hypoxic PHT and control groups. Combining conventional Doppler and DTI was more helpful to detect RV diastolic dysfunction in the monocrotaline PHT group (E/Ea ratio = 17.0 ± 1.4) compared with the hypoxic PHT and control groups (11.5 ± 0.7 and 10.2 ± 0.4, respectively). Tei index measured using DTI highlighted global RV dysfunction in the monocrotaline PHT group (1.36 ± 0.24 vs. 0.92 ± 0.05 and 0.86 ± 0.05 in the hypoxic PHT and control groups, respectively). Q-S_m time measured from the onset of Q wave to the onset of DTI S_m wave was increased in both PHT groups. PHT-induced electromechanical coupling alteration was confirmed by in vitro activation-contraction delay measurements on isolated RV papillary muscle, and both Q-S_m time and activation-contraction delay were correlated with PHT severity. We demonstrated that Q-S_m time measured in DTI was an easily and convenient index to detect early RV electromechanical coupling alteration in both moderate and severe PHT.

echocardiography; hypertrophy; right ventricular remodeling

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