HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 290/2/H512    most recent 01136.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Munzenmaier, D. H. Articles by Greene, A. S. Search for Related Content PubMed PubMed Citation Articles by Munzenmaier, D. H. Articles by Greene, A. S.

TRANSLATIONAL PHYSIOLOGY

Chronic angiotensin II AT₁ receptor blockade increases cerebral cortical microvessel density

Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin

Submitted 10 November 2004 ; accepted in final form 21 September 2005

Angiotensin II is known to stimulate angiogenesis in the peripheral circulation through activation of the angiotensin II type 1 (AT₁) receptor. This study investigated the effect of angiotensin receptor blockade on cerebral cortical microvessel density. Rats (6–7 wk old, n = 5–17) were instrumented with femoral arterial and venous indwelling catheters for arterial blood pressure measurement and drug administration. Rats were treated for 3 or 14 days with the AT₁ receptor blocker losartan (50 mg/day in drinking water) or vehicle. Brains were sectioned and immunostained for CD31, and microvessel density was measured. Treatment with losartan for 3 or 14 days resulted in a slight decrease in mean arterial blood pressure (3 days, 92 ± 1 mmHg; and 14 days, 99 ± 2 mmHg) compared with vehicle (109 ± 3 and 125 ± 4 mmHg, respectively). A furosemide + captopril 14-day treatment group was added to control for the blood pressure change (96 ± 3 mmHg). Microvessel density increased in groups treated with losartan for 14 days (429 ± 13 vessels/mm²) compared with vehicle (383 ± 11 vessels/mm²) but did not change with furosemide + captopril (364 ± 7 vessels/mm²). Thus AT₁ receptor blockade for 14 days resulted in increased cerebral microvessel density in a blood pressure-independent manner.

angiotensin receptor blockers; hypertension; microvascular growth

This article has been cited by other articles:

				S. Chen, G. Li, W. Zhang, J. Wang, C. D. Sigmund, J. E. Olson, and Y. Chen Ischemia-induced brain damage is enhanced in human renin and angiotensinogen double-transgenic mice Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2009; 297(5): R1526 - R1531. [Abstract] [Full Text] [PDF]

				G. K. Glantzounis, H. Sheth, C. Thompson, T. S. Hafez, S. Kanoria, V. Pamecha, S. Davies, D. P. Mikhailidis, A. M. Seifalian, and B. R. Davidson Acute Limb Ischemia Caused by Femoral Arterial Line Induces Remote Liver Injury in a Rabbit Model of Liver Ischemia/Reperfusion Injury Angiology, October 1, 2009; 60(5): 554 - 561. [Abstract] [PDF]

				E. H. Schlenker, M. Hora, Y. Liu, R. A. Redetzke, E. Morkin, and A. M. Gerdes Effects of thyroidectomy, T4, and DITPA replacement on brain blood vessel density in adult rats Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1504 - R1509. [Abstract] [Full Text] [PDF]