AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 290: H853-H860, 2006. First published August 26, 2005; doi:10.1152/ajpheart.00184.2005
0363-6135/06 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
290/2/H853    most recent
00184.2005v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (3)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Murai, H.
Right arrow Articles by Kaneko, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Murai, H.
Right arrow Articles by Kaneko, S.

The activity of a single muscle sympathetic vasoconstrictor nerve unit is affected by physiological stress in humans

Hisayoshi Murai,1 Shigeo Takata,2 Michiro Maruyama,1 Manabu Nakano,1 Daisuke Kobayashi,1 Kan-ichi Otowa,1 Masayuki Takamura,1 Toyoshi Yuasa,1 Satoru Sakagami,1 and Shuichi Kaneko1

Departments of 1Internal Medicine and 2Health Science, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan

Submitted 24 February 2005 ; accepted in final form 22 August 2005

Recording of neural firing from single-unit muscle sympathetic nerve activity (MSNA) is a new strategy offering information about the frequency of pure sympathetic firing. However, it is uncertain whether and when single-unit MSNA would be more useful than multiunit MSNA for analysis of various physiological stresses in humans. In 15 healthy subjects, we measured single-unit and multiunit MSNA before and during handgrip exercise at 30% of maximum voluntary contraction for 3 min and during the Valsalva maneuver at 40 mmHg expiratory pressure for 15 s. Shapes of individual single-unit MSNA were proved to be consistent and suitable for further evaluation. Single-unit and multiunit MSNA exhibited similar responses during handgrip exercise. However, acceleration of neural firing determined from single-unit MSNA became steeper than multiunit MSNA during the Valsalva maneuver. During the Valsalva maneuver, unlike handgrip exercise, the distribution of multiunit burst between 0, 1, 2, 3, and 4 spikes was significantly shifted toward multiple spikes within a given burst (P < 0.05). These results indicated that evaluation of single-unit MSNA could provide more detailed and accurate information concerning the role and responses of neuronal discharges induced by various physiological stresses in humans, especially amid intense sympathetic activity.

microneurography; handgrip exercise; Valsalva maneuver


Address for reprint requests and other correspondence: H. Murai, Dept. of Internal Medicine, Graduate School of Medical Science, Kanazawa Univ., 13–1 Takara-machi, Kanazawa 920–8641, Japan (e-mail: murai{at}medf.m.kanazawa-u.ac.jp)




This article has been cited by other articles:


Home page
 J. Physiol.Home page
H. Murai, M. Takamura, M. Maruyama, M. Nakano, T. Ikeda, D. Kobayashi, K.-i. Otowa, H. Ootsuji, M. Okajima, H. Furusho, et al.
Altered firing pattern of single-unit muscle sympathetic nerve activity during handgrip exercise in chronic heart failure
J. Physiol., June 1, 2009; 587(11): 2613 - 2622.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2006 by the American Physiological Society.