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This Article Full Text Full Text (PDF) All Versions of this Article: 290/3/H1145    most recent 00314.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Lynch, F. M. Articles by Izzard, A. S. Search for Related Content PubMed PubMed Citation Articles by Lynch, F. M. Articles by Izzard, A. S.

Adenosine and hypoxic dilation of rat coronary small arteries: roles of the ATP-sensitive potassium channel, endothelium, and nitric oxide

Cardiovascular Research Group, Department of Medicine, Manchester Royal Infirmary, Manchester, United Kingdom

Submitted 30 March 2005 ; accepted in final form 13 October 2005

The aims of the study were to examine the roles of the ATP-sensitive potassium (K_ATP) channel, the endothelium, and nitric oxide (NO) in the responses of rat coronary small arteries to adenosine and hypoxia. Segments of rat coronary vessel were investigated in vitro using pressure myography; all vessels studied developed stable spontaneous myogenic tone during equilibration. Glibenclamide (a K_ATP channel inhibitor) reversed pinacidil but not 2-deoxyglucose-induced dilation. Both adenosine and hypoxia dilated the vessels, and glibenclamide did not reverse these responses. Endothelial removal or N^G-nitro-L-arginine methyl ester (L-NAME) inhibited the dilation to adenosine by 50%; subsequent addition of glibenclamide was without effect. Hypoxic dilation was completely inhibited by endothelium removal or L-NAME. We conclude that adenosine- and hypoxia-induced dilation of rat coronary arteries does not appear to involve the K_ATP channel. Adenosine-induced dilation is partially and hypoxic dilation is completely dependent on endothelium-derived NO.

myogenic tone; hypoxia

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				K. M. Gauthier Hypoxia-induced vascular smooth muscle relaxation: increased ATP-sensitive K+ efflux or decreased voltage-sensitive Ca2+ influx? Am J Physiol Heart Circ Physiol, July 1, 2006; 291(1): H24 - H25. [Full Text] [PDF]