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This Article Full Text Full Text (PDF) All Versions of this Article: 290/4/H1534    most recent 00742.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Labat, C. Articles by Lacolley, P. Search for Related Content PubMed PubMed Citation Articles by Labat, C. Articles by Lacolley, P.

Respective contribution of age, mean arterial pressure, and body weight on central arterial distensibility in SHR

¹INSERM U684, Nancy, France; ²Hôtel-Dieu Hospital, Diagnosis center, Paris, France; ³UFES, Clinica de Investigaçao cardiovascular, Vitoria, Brazil; ⁴CNRS, FRE 2867, Paris, France; ⁵Université Henri Poincaré, UFR Médecine, Nancy, France; ⁶Université Pierre et Marie Curie, UFR923, Paris, France; and ⁷Université René Descartes, UFR Médecine, Paris, France

Submitted 14 July 2005 ; accepted in final form 12 October 2005

In spontaneously hypertensive rats (SHR), carotid and aortic distensibilities measured at operational blood pressure (BP) are reduced. Increased body weight and mean arterial pressure (MAP) are both known to reduce distensibility independently. However, whether, after adjustment to body weight and mean BP, distensibility remains reduced in SHR has never been investigated. Carotid and abdominal aorta distensibilities were measured under anesthesia in SHR at 5, 12, 52, and 78 wk of age, and measurements were compared with age-matched normotensive Wistar rats. Each age group was composed of 9 or 10 animals. We determined distensibility using echo-tracking techniques of high resolution. Compared with Wistar rats, carotid and aortic distensibilities measured at operational MAP are reduced in SHR. This reduction is accentuated with age, particularly for the carotid artery. After adjustment to body weight and MAP, carotid and aortic distensibilities become identical in Wistar and SHR (or even slightly increased in SHR) but continue to be reduced with age, mainly for the carotid artery. In conclusion, in SHR, age and high BP do not have a parallel and similar influence on the reduction of arterial distensibility. Aging constantly reduces arterial distensibility, whereas MAP levels contribute to maintenance of arterial function.

spontaneously hypertensive rats; carotid distensibility

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