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This Article Full Text Full Text (PDF) All Versions of this Article: 290/4/H1540    most recent 00935.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (11) Citing Articles via Google Scholar Google Scholar Articles by Jegger, D. Articles by Stergiopulos, N. Search for Related Content PubMed PubMed Citation Articles by Jegger, D. Articles by Stergiopulos, N.

Noninvasive Doppler-derived myocardial performance index in rats with myocardial infarction: validation and correlation by conductance catheter

¹Laboratory of Hemodynamics and Cardiovascular Technology, Ecole Polytechnique Fédérale de Lausanne; and ²Department of Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne; ³Department of Cardiovascular Surgery, Inselspital, Bern; ⁴Departments of Cardiology and ⁵Anesthesiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; and ⁶Hydraulics Laboratory, Institute of Biomedical Technology, Ghent University, Gent, Belgium

Submitted 1 September 2005 ; accepted in final form 11 November 2005

The rodent model of myocardial infarction (MI) is extensively used in heart failure studies. However, long-term follow-up of echocardiographic left ventricular (LV) function parameters such as the myocardial performance index (MPI) and its ratio with the fractional shortening (LVFS/MPI) has not been validated in conjunction with invasive indexes, such as those derived from the conductance catheter (CC). Sprague-Dawley rats with left anterior descending coronary artery ligation (MI group, n = 9) were compared with a sham-operated control group (n = 10) without MI. Transthoracic echocardiography (TTE) was performed every 2 wk over an 8-wk period, after which classic TTE parameters, especially MPI and LVFS/MPI, were compared with invasive indexes obtained by using a CC. Serial TTE data showed significant alterations in the majority of the noninvasive functional and structural parameters (classic and novel) studied in the presence of MI. Both MPI and LVFS/MPI significantly (P < 0.05 for all reported values) correlated with body weight (r = –0.58 and 0.76 for MPI and LVFS/MPI, respectively), preload recruitable stroke work (r = –0.61 and 0.63), LV end-diastolic pressure (LVEDP) (r = 0.82 and –0.80), end-diastolic volume (r = 0.61 and –0.58), and end-systolic volume (r = 0.46 and –0.48). Forward stepwise linear regression analysis revealed that, of all variables tested, LVEDP was the only independent determinant of MPI (r = 0.84) and LVFS/MPI (r = 0.83). We conclude that MPI and LVFS/MPI correlate strongly and better than the classic noninvasive TTE parameters with established, invasively assessed indexes of contractility, preload, and volumetry. These findings support the use of these two new noninvasive indexes for long-term analysis of the post-MI LV remodeling.

echocardiography; heart failure; hemodynamics; ventricular function

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