AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 291: H948-H956, 2006. First published April 14, 2006; doi:10.1152/ajpheart.00734.2005
0363-6135/06 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
291/2/H948    most recent
00734.2005v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (5)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bureau, W.
Right arrow Articles by Dumont, D. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bureau, W.
Right arrow Articles by Dumont, D. J.

Chronic systemic delivery of angiopoietin-2 reveals a possible independent angiogenic effect

W. Bureau,1,2 P. Van Slyke,1,2 J. Jones,1 R. N. N. Han,3 Nicole L. Ward,6 D. J. Stewart,3,4,5 and D. J. Dumont1,2,4,5

1Molecular and Cellular Biology Research, Sunnybrook and Women’s Research Institute; 2Department of Medical Biophysics; 3Terrence Donnelly Heart Center, Division of Cardiology, St. Michael’s Hospital and the Department of Medicine; 4Heart and Stroke/Richard Lewar Centre of Excellence, Faculty of Medicine, University of Toronto; 5R. Samuel McLaughlin Centre for Molecular Medicine, Toronto, Ontario, Canada; and 6Departments of Dermatology and Neurosciences, School of Medicine; Case Western Reserve University, Cleveland, Ohio

Submitted 10 July 2005 ; accepted in final form 15 March 2006

Angiopoietin-2 has been implicated in the angiogenic response; however, this response has been tied to the expression of VEGF, and an independent angiogenic role has yet to be described. In this report, we detail the generation of transgenic mice that conditionally express angiopoietin-2 in the liver, resulting in sustained increases in circulating levels. These animals survive gestation and present with several vascular abnormalities, including an increase in the diameter of myocardial coronary vessels and a reduction in the density of endocardial vessels. In the lung, prominent increases in vessel diameter were observed. These vascular remodeling changes occurred in the absence of any apparent increase in VEGF expression. Our results illustrate that chronic systemic delivery of angiopoietin-2 induces angiogenesis in the absence of increased VEGF expression and that angiopoietin-2 promotes myocardial coronary vessel remodeling.

hemorrhage; lymphangiogenesis


Address for reprint requests and other correspondence: D. J. Dumont, Sunnybrook and Women’s Research Institute, 2075 Bayview Ave., Rm. S218, Toronto, ONT, Canada M4N 3M5 (e-mail: dan.dumont{at}sri.utoronto.ca)




This article has been cited by other articles:


Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
J.-X. Chen and A. Stinnett
Disruption of Ang-1/Tie-2 Signaling Contributes to the Impaired Myocardial Vascular Maturation and Angiogenesis in Type II Diabetic Mice
Arterioscler. Thromb. Vasc. Biol., September 1, 2008; 28(9): 1606 - 1613.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Q.-h. Tuo, H. Zeng, A. Stinnett, H. Yu, J. L. Aschner, D.-F. Liao, and J.-X. Chen
Critical role of angiopoietins/Tie-2 in hyperglycemic exacerbation of myocardial infarction and impaired angiogenesis
Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2547 - H2557.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
S. L. Tressel, R.-P. Huang, N. Tomsen, and H. Jo
Laminar Shear Inhibits Tubule Formation and Migration of Endothelial Cells by an Angiopoietin-2-Dependent Mechanism
Arterioscler. Thromb. Vasc. Biol., October 1, 2007; 27(10): 2150 - 2156.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
B. Davis, A. Dei Cas, D. A. Long, K. E. White, A. Hayward, C.-H. Ku, A. S. Woolf, R. Bilous, G. Viberti, and L. Gnudi
Podocyte-Specific Expression of Angiopoietin-2 Causes Proteinuria and Apoptosis of Glomerular Endothelia
J. Am. Soc. Nephrol., August 1, 2007; 18(8): 2320 - 2329.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
Y. Reiss, J. Droste, M. Heil, S. Tribulova, M. H.H. Schmidt, W. Schaper, D. J. Dumont, and K. H. Plate
Angiopoietin-2 Impairs Revascularization After Limb Ischemia
Circ. Res., July 6, 2007; 101(1): 88 - 96.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
F.-C. Ye, D. J. Blackbourn, M. Mengel, J.-P. Xie, L.-W. Qian, W. Greene, I-T. Yeh, D. Graham, and S.-J. Gao
Kaposi's Sarcoma-Associated Herpesvirus Promotes Angiogenesis by Inducing Angiopoietin-2 Expression via AP-1 and Ets1
J. Virol., April 15, 2007; 81(8): 3980 - 3991.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2006 by the American Physiological Society.