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This Article Full Text Full Text (PDF) All Versions of this Article: 291/3/H1200    most recent 01323.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (8) Citing Articles via Google Scholar Google Scholar Articles by Wang, C. Articles by Kassab, G. S. Search for Related Content PubMed PubMed Citation Articles by Wang, C. Articles by Kassab, G. S.

Three-dimensional mechanical properties of porcine coronary arteries: a validated two-layer model

Departments of ¹Mechanical and Aerospace Engineering and ²Biomedical Engineering, University of California, Irvine, California; and ³Department of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel

Submitted 15 December 2005 ; accepted in final form 22 March 2006

The normal coronary artery consists of two mechanically distinct layers: intima-media and adventitia. The objective of this study is to establish a two-layer three-dimensional (3-D) stress-strain relation of porcine coronary arteries. Experimental measurements were made by a series of biaxial tests (inflation and axial extension) of intact coronary arteries and, subsequently, their corresponding intima-media or adventitia layer. The Fung-type exponential strain energy function was used to describe the 3-D strain-stress relation for each layer and the intact wall. A genetic algorithm was used to determine the material constants in the Fung-type constitutive equation by curve fitting the experimental data. Because one layer must be sacrificed before the other layer can be tested, the material property of the missing layer was computed from the material constants of the intact vessel and the tested layer. A total of 20 porcine hearts were used: one group of 10 hearts for the left anterior descending artery and another group of 10 hearts for the right coronary artery. Each group was further divided into two subgroups of five specimens tested for the intact wall and the intima-media layer and for the intact wall and the adventitia layer. Our results show statistically significant differences in the material properties of the two layers. The mathematical model was validated by experimental stress-strain data for individual layers. The validated 3-D constitutive model will serve as a foundation for formulation of layer-specific boundary value problems in coronary physiology and cardiology.

stress-strain relation; constitutive relation; intima-media; adventitia; strain energy function

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