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INNOVATIVE METHODOLOGY
School of Medical Sciences (Physiology) and Bosch Institute for Biomedical Research, University of Sydney, Australia
Submitted 1 March 2006 ; accepted in final form 15 May 2006
The logistic sigmoid function curve provides an accurate description of the baroreflex input-output relationship and is the most commonly used equation for this purpose. The threshold (Thr) and saturation (Sat) values for the baroreflex are commonly defined as the values of mean arterial pressure (MAP) at which the reflexly controlled variable (e.g., heart rate or sympathetic nerve activity) is within 5% of the upper or lower plateau, respectively, of the sigmoid function. These values are referred to here as Thr5% and Sat5%. In many studies, Thr and Sat are calculated with the equations Thr = A3 – 2.0/A2 and Sat = A3 + 2.0/A2, where A3 is the value of MAP at the point where the reflexly controlled variable is at the midpoint of its range and A2 is the gain coefficient. Although it is commonly stated that the values of Thr and Sat calculated with these equations represent Thr5% and Sat5%, we show here that instead they are significantly greater and less than Thr5% and Sat5%, respectively. Furthermore, the operating range (difference between Thr and Sat) calculated with these equations is 32% less than the difference between Thr5% and Sat5%. We further show that the equations that provide correct values of Thr5% and Sat5% are Thr5% = A3 – 2.944/A2 and Sat5% = A3 + 2.944/A2. We propose that these be used as the standard equations for calculating threshold and saturation values when a logistic sigmoid function is used to model the open-loop baroreflex function curve.
mathematical modeling; input-output relationship; baroreflex operating range; regression analysis
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