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This Article Full Text Full Text (PDF) All Versions of this Article: 291/6/H2752    most recent 01164.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (5) Citing Articles via Google Scholar Google Scholar Articles by Wang, Q. Articles by Song, Q. Search for Related Content PubMed PubMed Citation Articles by Wang, Q. Articles by Song, Q.

Association study of CRP gene polymorphisms with serum CRP level and cardiovascular risk in the NHLBI Family Heart Study

¹Cardiovascular Research Institute and ²Clinical Research Center, Morehouse School of Medicine, Atlanta, Georgia; ³Cardiovascular Genetics Division, University of Utah, Salt Lake City, Utah; ⁴Division of Biostatistics, Washington University, St. Louis, Missouri; ⁵Department of Laboratory Medicine and Pathology and ⁶Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; and ⁷Cardiovascular Center, University of Michigan Medical Center, Ann Arbor, Michigan

Submitted 3 November 2005 ; accepted in final form 25 May 2006

Recent epidemiological studies have indicated that baseline C-reactive protein (CRP) levels may have value in prediction of cardiovascular risk. Using six tag single-nucleotide polymorphisms (SNPs) selected from our complete list of SNPs on the CRP gene, we investigated the association of CRP genotypes with plasma CRP levels and cardiovascular risk in the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study cohort (1,296 Caucasians, 48.5% male, 54.7 ± 12.8 yr old). There was a significant trend toward association of CRP haplotypes with CRP levels (P = 0.045). SNP analysis indicated a highly significant association of SNP –757 (rs3093059, P = 0.0004) and SNP –286 (rs3091244, P = 0.0065) and a borderline association of SNP –7180 (rs1341665, P = 0.06) with CRP levels. Neither CRP haplotypes nor individual SNP genotypes were associated with intima-media thickness of the common carotid or internal carotid artery or the bifurcation of the carotid arteries. These results indicated a strong impact of local SNPs of the CRP gene on plasma CRP levels, but there was no direct evidence that these genetically controlled CRP elevations by local CRP SNPs contributed to cardiovascular disease phenotypes.

epidemiology; single-nucleotide polymorphism; coronary heart disease

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