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This Article Full Text Full Text (PDF) All Versions of this Article: 291/6/H2758    most recent 00610.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (4) Citing Articles via Google Scholar Google Scholar Articles by Shou, Y. Articles by Rumschitzki, D. S. Search for Related Content PubMed PubMed Citation Articles by Shou, Y. Articles by Rumschitzki, D. S.

Transport in rat vessel walls. I. Hydraulic conductivities of the aorta, pulmonary artery, and inferior vena cava with intact and denuded endothelia

¹Department of Chemical Engineering, City College and Graduate School and University Center, City University of New York; and ²Columbia College of Physicians and Surgeons, New York, New York

Submitted 7 June 2005 ; accepted in final form 21 May 2006

In this study, filtration flows through the walls of the rat aorta, pulmonary artery (PA), and inferior vena cava (IVC), vessels with very different susceptibilities to atherosclerosis, were measured as a function of transmural pressure (P), with intact and denuded endothelium on the same vessel. Aortic hydraulic conductivity (L_p) is high at 60 mmHg, drops 40% by 100 mmHg, and is pressure independent to 140 mmHg. The trends are similar in the PA and IVC, dropping 42% from 10 to 40 mmHg and flat to 100 mmHg (PA) and dropping 33% from 10 to 20 mmHg and essentially flat to 60 mmHg (IVC). Removal of the endothelium renders L_p(P) flat: it increases L_p of the aorta by 75%, doubles L_p of the PA, and quadruples L_p of the IVC. Specific resistance (1/L_p) of the aortic endothelium is 47% of total resistance; i.e., the endothelium accounts for 47% of the P drop at 100 mmHg. The PA value is 55% at >40 mmHg, and the IVC value is 23% at 10 mmHg. L_p of the intact aorta, PA, and IVC are order 10^–8_, 10^–7, and 5 x 10^–7 cm·s^–1·mmHg^–1, and wall thicknesses are 145.8 µm (SD 9.3), 78.9 µm (SD 3.3), and 66.1 µm (SD 4.1), respectively. These data are consistent with the different wall structures of the three vessels. The rat aortic L_p data are quantitatively consistent with rabbit L_p(P) (Tedgui A and Lever MJ. Am J Physiol Heart Circ Physiol 247: H784–H791, 1984; Baldwin AL and Wilson LM. Am J Physiol Heart Circ Physiol 264: H26–H32, 1993), suggesting that intimal compression under pressure loading may also play a role in L_p(P) in these other vessels. Despite very different driving P, nominal transmural water fluxes of these three vessels are very similar and, therefore, cannot alone account for their differences in disease susceptibility. The different fates of macromolecular tracers convected by these water fluxes into the walls of these vessels may account for this difference.

transmural water flow; filtration; intima compression

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