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Effects of intravascular infusions of plasma on placental and systemic blood flow in fetal sheep

Departments of ¹Physiology and Pharmacology, ⁵Obstetrics and Gynecology, and ²Medicine, ³Heart Research Center, Oregon Health and Sciences University, and the ⁴Portland Veterans Affairs Medical Center, Portland, Oregon

Submitted 30 April 2006 ; accepted in final form 3 August 2006

Six singleton fetal sheep of 118–122 days gestational age were instrumented with flow sensors on the brachiocephalic artery, the postductal aorta, and the common umbilical artery and with arterial and venous intravascular catheters. At 125–131 days of gestation, we started week-long continuous recordings of flows and pressures. After control measures had been obtained, the fetuses were given continuous intravenous infusions of adult sheep plasma at an initial rate of 229 ml/day. After 1 wk of infusion, fetal plasma protein concentrations had increased from 34 to 78 g/l, arterial and venous pressures had increased from 42 to 64 and from 2.7 to 3.7 mmHg, and systemic resistance (exclusive of the coronary bed) had increased from 0.047 to 0.075 mmHg·min^–1·ml^–1, whereas placental resistance had increased from 0.065 to 0.111 mmHg·min^–1·ml^–1. Fetal plasma renin activities fell as early as 1 day after the start of infusion and remained below control (all changes P < 0.05). All flows decreased slightly although these decreases were not statistically significant. Thus the increase in arterial pressure was entirely due to an increase in systemic and placental resistances.

fetal sheep; blood pressure; placental flow; systemic flow; placental resistance; systemic resistance

This article has been cited by other articles:

				S. S. Jonker, J. J. Faber, D. F. Anderson, K. L. Thornburg, S. Louey, and G. D. Giraud Sequential growth of fetal sheep cardiac myocytes in response to simultaneous arterial and venous hypertension Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R913 - R919. [Abstract] [Full Text] [PDF]