| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1Noll Laboratory, 2Department of Kinesiology, and 3Physiology Program, The Pennsylvania State University, University Park, Pennsylvania
Submitted 22 February 2006 ; accepted in final form 14 July 2006
Previous investigations of age-associated changes in flow-mediated vasodilation (FMD) in women have been limited to the upper extremity and have not accounted for possible age differences in the stimulus for dilation. The purpose of the present study was to compare age differences in brachial and popliteal FMD and its stimulus (changes in shear rate following occlusion). Ultrasound-derived diameters and Doppler flow velocities of the brachial and popliteal arteries were measured in 14 young (20- to 30-yr-old) and 14 older (60- to 79-yr-old) healthy women at rest and during and after 5 min of distal cuff occlusion. Resting diameters were similar (both P > 0.39) in both age groups. Peak shear rate did not differ with age in either artery: 
1,300–1,400 and 400–500 s–1 in brachial and popliteal arteries, respectively. FMD (percent change above diameter measured during occlusion) was 50–60% lower (P < 0.05) in the brachial (15.8 + 0.8% vs. 8.1 + 1.5%) and popliteal (4.6 ± 0.7% vs. 1.8 ± 0.4%) arteries of the older women. The normalized response of the brachial and popliteal arteries (%FMD per unit change in shear rate) was also reduced with age (55% and 53%, respectively) but did not exhibit limb specificity. Additionally, endothelium-independent dilation, as assessed by administration of nitroglycerin, was similarly blunted (by 45–65%) in brachial and popliteal arteries of older women. These results suggest that 1) brachial and popliteal artery FMD (after 5 min of distal occlusion) are similarly reduced with age, 2) when normalized to the change in shear stimulus, both arteries are equally responsive to 5 min of distal cuff occlusion in women, and 3) the age-associated decline in FMD may be attributable in part to diminished smooth muscle responsiveness.
vascular responsiveness; endothelial function; limb-specific dilation
This article has been cited by other articles:
|
|
 |
|
  B. S. Kirby, W. F. Voyles, C. B. Simpson, R. E. Carlson, W. G. Schrage, and F. A. Dinenno Endothelium-dependent vasodilatation and exercise hyperaemia in ageing humans: impact of acute ascorbic acid administration J. Physiol., May 1, 2009; 587(9): 1989 - 2003. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. W. Wray, S. K. Nishiyama, and R. S. Richardson Role of {alpha}1-adrenergic vasoconstriction in the regulation of skeletal muscle blood flow with advancing age Am J Physiol Heart Circ Physiol, February 1, 2009; 296(2): H497 - H504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. J. Thijssen, L. M. Bullens, M. M. van Bemmel, E. A. Dawson, N. Hopkins, T. M. Tinken, M. A. Black, M. T. E. Hopman, N. T. Cable, and D. J. Green Does arterial shear explain the magnitude of flow-mediated dilation?: a comparison between young and older humans Am J Physiol Heart Circ Physiol, January 1, 2009; 296(1): H57 - H64. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Nishiyama, D. W. Wray, and R. S. Richardson Aging affects vascular structure and function in a limb-specific manner J Appl Physiol, November 1, 2008; 105(5): 1661 - 1670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. J. Thijssen, M. M. van Bemmel, L. M. Bullens, E. A. Dawson, N. D. Hopkins, T. M. Tinken, M. A. Black, M. T. E. Hopman, N. T. Cable, and D. J. Green The impact of baseline diameter on flow-mediated dilation differs in young and older humans Am J Physiol Heart Circ Physiol, October 1, 2008; 295(4): H1594 - H1598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Nishiyama, D. W. Wray, and R. S. Richardson Sex and limb-specific ischemic reperfusion and vascular reactivity Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H1100 - H1108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Newcomer, C. L. Sauder, N. T. Kuipers, M. H. Laughlin, and C. A. Ray Effects of posture on shear rates in human brachial and superficial femoral arteries Am J Physiol Heart Circ Physiol, April 1, 2008; 294(4): H1833 - H1839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Parker, S. L. Smithmyer, J. A. Pelberg, A. D. Mishkin, and D. N. Proctor Sex-specific influence of aging on exercising leg blood flow J Appl Physiol, March 1, 2008; 104(3): 655 - 664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kooijman, D. H. J. Thijssen, P. C. E. de Groot, M. W. P. Bleeker, H. J. M. van Kuppevelt, D. J. Green, G. A. Rongen, P. Smits, and M. T. E. Hopman Flow-mediated dilatation in the superficial femoral artery is nitric oxide mediated in humans J. Physiol., February 15, 2008; 586(4): 1137 - 1145. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Black, N. T. Cable, D. H.J. Thijssen, and D. J. Green Importance of Measuring the Time Course of Flow-Mediated Dilatation in Humans Hypertension, February 1, 2008; 51(2): 203 - 210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Nishiyama, D. Walter Wray, K. Berkstresser, M. Ramaswamy, and R. S. Richardson Limb-specific differences in flow-mediated dilation: the role of shear rate J Appl Physiol, September 1, 2007; 103(3): 843 - 851. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Yeboah, J. R. Crouse, F.-C. Hsu, G. L. Burke, and D. M. Herrington Brachial Flow-Mediated Dilation Predicts Incident Cardiovascular Events in Older Adults: The Cardiovascular Health Study Circulation, May 8, 2007; 115(18): 2390 - 2397. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
