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17-Estradiol modulates vasoconstriction induced by endothelin-1 following trauma-hemorrhage

Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama

Submitted 28 July 2006 ; accepted in final form 20 August 2006

Although endothelin-1 (ET-1) induces vasoconstriction, it remains unknown whether 17-estradiol (E₂) treatment following trauma-hemorrhage alters these ET-1-induced vasoconstrictive effects. In addition, the role of the specific estrogen receptor (ER) subtypes (ER- and ER-) and the endothelium-localized downstream mechanisms of actions of E₂ remain unclear. We hypothesized that E₂ attenuates increased ET-1-induced vasoconstriction following trauma-hemorrhage via an ER--mediated pathway. To study this, aortic rings were isolated from male Sprague-Dawley rats following trauma-hemorrhage with or without E₂ treatment, and alterations in tension were determined in vitro. Dose-response curves to ET-1 were determined, and the vasoactive properties of E₂, propylpyrazole triol (PPT, ER- agonist), and diarylpropionitrile (DPN, ER- agonist) were determined. The results showed that trauma-hemorrhage significantly increased ET-1-induced vasoconstriction; however, administration of E₂ normalized ET-1-induced vasoconstriction in trauma-hemorrhage vessels to the sham-operated control level. The ER- agonist DPN counteracted ET-1-induced vasoconstriction, whereas the ER- agonist PPT was ineffective. Moreover, the vasorelaxing effects of E₂ were not observed in endothelium-denuded aortic rings or by pretreatment of the rings with a nitric oxide (NO) synthase inhibitor. Cyclooxygenase inhibition with indomethacin had no effect on the action of E₂. Thus, E₂ administration attenuates ET-1-induced vasoconstriction following trauma-hemorrhage via an ER--mediated pathway that is dependent on endothelium-derived NO synthesis.

estrogen receptor; nitric oxide; endothelium; aortic ring

This article has been cited by other articles:

				Z. F. Ba and I. H. Chaudry Role of estrogen receptor subtypes in estrogen-induced organ-specific vasorelaxation after trauma-hemorrhage Am J Physiol Heart Circ Physiol, November 1, 2008; 295(5): H2061 - H2067. [Abstract] [Full Text] [PDF]